Efficient Iron-Catalyzed Reductive N-Alkylation of Aromatic Amines with Carboxylic Acid and Phenylsilane

被引：19

作者：

Qiao, Chang ^{[1
,2
]}

Yao, Xiang-Yang ^{[1
,2
]}

Liu, Xiao-Fang ^{[1
,2
]}

Li, Hong-Ru ^{[3
,4
]}

He, Liang-Nian ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab, Coll Chem, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China

[3] Nankai Univ, Coll Pharm, Tianjin 300353, Peoples R China

[4] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300353, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 09期

基金：

中国国家自然科学基金;

关键词：

alkylation; anilines; carboxylic acids; hydrosilanes; iron; FORMIC-ACID; CARBON-DIOXIDE; HYDROGEN SOURCE; METHYLATION; METHANOL; CO2; AMINATION; ENERGY; HYDROSILYLATION; HYDROSILANES;

D O I：

10.1002/ajoc.201800420

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of efficient catalysts for the alkylation of amines with carboxylic acids is attracting much attention. Herein, we would like to report an earth-abundant iron-catalyzed protocol for the N-alkylation of anilines using carboxylic acid as alkyl source and phenylsilane as reducing agent. With Fe-2(CO)(9) as a catalyst, a broad range of primary and secondary anilines are successfully converted to the corresponding tertiary anilines. Furthermore, this N-alkylation mainly goes through the amide pathway; while the aldehyde pathway can not be ruled out.

引用

页码：1815 / 1818

页数：4

共 55 条

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