The emerging importance of group II PAKs

被引：116

作者：

Wells, Claire M. ^{[1
]}

Jones, Gareth E. ^{[2
]}

机构：

[1] Kings Coll London, Div Canc Studies, London SE1 1UL, England

[2] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England

来源：

BIOCHEMICAL JOURNAL | 2010年 / 425卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

actin cytoskeleton; cancer; inflammatory response; knockout-mouse study; neurological disorder; p21-activated kinase (PAK); NUCLEOTIDE EXCHANGE FACTOR; P21-ACTIVATED KINASE; PROSTATE-CANCER; CELL-ADHESION; SERINE/THREONINE KINASE; PREMATURE SENESCENCE; NEURITE OUTGROWTH; COLORECTAL-CANCER; GROWTH-FACTOR; RHO FAMILY;

D O I：

10.1042/BJ20091173

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Rho-family GTPases Rho Rac and Cdc42 regulate many intracellular processes through their interaction with downstream effector proteins. The PAKs (p21-activated kinases) are a family of effector proteins for Rac and Cdc42. PAKs are important regulators of actin cytoskeletal dynamics, neurrite outgrowth, cell Survival, hormone signalling and gene transcription. There are six mammalian PAKs that can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar, there are differences in their mode of regulation, suggesting that their cellular functions are likely to be different. Whereas much is known about group I PAKs, less is known about the more recently discovered PAK4, PAK5 and PAK6. This review will focus on the latest structural and functional results relating to the group II PAKs and discuss the emerging importance of group II PAKs in disease progression.

引用

页码：465 / 473

页数：9

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