Pediatric Brain Tumors

被引:195
作者
Udaka, Yoko T. [1 ,2 ]
Packer, Roger J. [1 ,3 ]
机构
[1] Childrens Natl Hlth Syst, Ctr Neurosci & Behav Med, Brain Tumor Inst, 111 Michigan Ave Northwest, Washington, DC 20010 USA
[2] Ctr Canc & Blood Disorders, Div Oncol, 111 Michigan Ave Northwest, Washington, DC 20010 USA
[3] Childrens Natl Med Ctr, Brain Tumor Inst, Gilbert Family Neurofibromatosis Inst, 111 Michigan Ave Northwest, Washington, DC 20010 USA
关键词
Brain tumors; Pediatric brain tumors; Medulioblastoma; Gliomas; Embryonal tumors; CENTRAL-NERVOUS-SYSTEM; GERM-CELL TUMORS; SPINAL-CORD TUMORS; CHOROID-PLEXUS CARCINOMA; HIGH-GRADE ASTROCYTOMA; HIGH-DOSE CHEMOTHERAPY; ATYPICAL TERATOID/RHABDOID TUMORS; PRIMITIVE NEUROECTODERMAL TUMORS; TERATOID RHABDOID TUMORS; PHASE-III TRIAL;
D O I
10.1016/j.ncl.2018.04.009
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Pediatric central nervous system (CNS) tumors are the most common solid tumors in children and comprise 15% to 20% of all malignancies in children. Presentation, symptoms, and signs depend on tumor location and age of the patient at the time of diagnosis. This article summarizes the common childhood CNS tumors, presentations, classification, and recent updates in treatment approaches owing to the increased understanding of the molecular pathogenesis of pediatric brain tumors.
引用
收藏
页码:533 / +
页数:25
相关论文
共 152 条
[61]   Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1 [J].
Josupeit, Rafael ;
Bender, Sebastian ;
Kern, Sonja ;
Leuchs, Barbara ;
Hielscher, Thomas ;
Herold-Mende, Christel ;
Schlehofer, Joerg R. ;
Dinsart, Christiane ;
Witt, Olaf ;
Rommelaere, Jean ;
Lacroix, Jeannine .
VIRUSES-BASEL, 2016, 8 (05)
[62]   Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis Clinical article [J].
Kanamori, Masayuki ;
Kumabe, Toshihiro ;
Saito, Ryuta ;
Yamashita, Yoji ;
Sonoda, Yukihiko ;
Ariga, Hisanori ;
Takai, Yoshihiro ;
Tominaga, Teiji .
JOURNAL OF NEUROSURGERY-PEDIATRICS, 2009, 4 (06) :506-514
[63]   Pediatric Ependymoma: Biological Perspectives [J].
Kilday, John-Paul ;
Rahman, Ruman ;
Dyer, Sara ;
Ridley, Lee ;
Lowe, James ;
Coyle, Beth ;
Grundy, Richard .
MOLECULAR CANCER RESEARCH, 2009, 7 (06) :765-786
[64]   Cerebral intraventricular neoplasms: Radiologic-pathologic correlation [J].
Koeller, KK ;
Sandberg, GD .
RADIOGRAPHICS, 2002, 22 (06) :1473-1505
[65]   Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition [J].
Kool, Marcel ;
Jones, David T. W. ;
Jaeger, Natalie ;
Northcott, Paul A. ;
Pugh, Trevor J. ;
Hovestadt, Volker ;
Piro, Rosario M. ;
Esparza, L. Adriana ;
Markant, Shirley L. ;
Remke, Marc ;
Milde, Till ;
Bourdeaut, Franck ;
Ryzhova, Marina ;
Sturm, Dominik ;
Pfaff, Elke ;
Stark, Sebastian ;
Hutter, Sonja ;
Seker-Cin, Huriye ;
Johann, Pascal ;
Bender, Sebastian ;
Schmidt, Christin ;
Rausch, Tobias ;
Shih, David ;
Reimand, Jueri ;
Sieber, Laura ;
Wittmann, Andrea ;
Linke, Linda ;
Witt, Hendrik ;
Weber, Ursula D. ;
Zapatka, Marc ;
Koenig, Rainer ;
Beroukhim, Rameen ;
Bergthold, Guillaume ;
van Sluis, Peter ;
Volckmann, Richard ;
Koster, Jan ;
Versteeg, Rogier ;
Schmidt, Sabine ;
Wolf, Stephan ;
Lawerenz, Chris ;
Bartholomae, Cynthia C. ;
von Kalle, Christof ;
Unterberg, Andreas ;
Herold-Mende, Christel ;
Hofer, Silvia ;
Kulozik, Andreas E. ;
von Deimling, Andreas ;
Scheurlen, Wolfram ;
Felsberg, Joerg ;
Reifenberger, Guido .
CANCER CELL, 2014, 25 (03) :393-405
[66]   Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas [J].
Kool, Marcel ;
Korshunov, Andrey ;
Remke, Marc ;
Jones, David T. W. ;
Schlanstein, Maria ;
Northcott, Paul A. ;
Cho, Yoon-Jae ;
Koster, Jan ;
Schouten-van Meeteren, Antoinette ;
van Vuurden, Dannis ;
Clifford, Steven C. ;
Pietsch, Torsten ;
von Bueren, Andre O. ;
Rutkowski, Stefan ;
McCabe, Martin ;
Collins, V. Peter ;
Backlund, Magnus L. ;
Haberler, Christine ;
Bourdeaut, Franck ;
Delattre, Olivier ;
Doz, Francois ;
Ellison, David W. ;
Gilbertson, Richard J. ;
Pomeroy, Scott L. ;
Taylor, Michael D. ;
Lichter, Peter ;
Pfister, Stefan M. .
ACTA NEUROPATHOLOGICA, 2012, 123 (04) :473-484
[67]   Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features [J].
Kool, Marcel ;
Koster, Jan ;
Bunt, Jens ;
Hasselt, Nancy E. ;
Lakeman, Arjan ;
van Sluis, Peter ;
Troost, Dirk ;
Schouten-van Meeteren, Netteke ;
Caron, Huib N. ;
Cloos, Jacqueline ;
Mrsic, Alan ;
Ylstra, Bauke ;
Grajkowska, Wieslawa ;
Hartmann, Wolfgang ;
Pietsch, Torsten ;
Ellison, David ;
Clifford, Steven C. ;
Versteeg, Rogier .
PLOS ONE, 2008, 3 (08)
[68]   Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: A children's oncology group phase II study [J].
Korones, David N. ;
Fisher, Paul G. ;
Kretschmar, Cynthia ;
Zhou, Tianni ;
Chen, Zhengjia ;
Kepner, James ;
Freeman, Carolyn .
PEDIATRIC BLOOD & CANCER, 2008, 50 (02) :227-230
[69]   Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma Clinical article [J].
Lafay-Cousin, Lucie ;
Mabbott, Donald J. ;
Halliday, William ;
Taylor, Michael D. ;
Tabori, Uri ;
Kamaly-Asl, Ian D. ;
Kulkarni, Abhaya V. ;
Bartels, Ute ;
Greenberg, Mark ;
Bouffet, Eric .
JOURNAL OF NEUROSURGERY-PEDIATRICS, 2010, 5 (06) :615-621
[70]   Phase II Weekly Vinblastine for Chemotherapy-Naive Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study [J].
Lassaletta, Alvaro ;
Scheinemann, Katrin ;
Zelcer, Shayna M. ;
Hukin, Juliette ;
Wilson, Beverley A. ;
Jabado, Nada ;
Carret, Anne Sophie ;
Lafay-Cousin, Lucie ;
Larouche, Valerie ;
Hawkins, Cynthia E. ;
Pond, Gregory Russell ;
Poskitt, Ken ;
Keene, Daniel ;
Johnston, Donna L. ;
Eisenstat, David D. ;
Krishnatry, Rahul ;
Mistry, Matthew ;
Arnoldo, Anthony ;
Ramaswamy, Vijay ;
Huang, Annie ;
Bartels, Ute ;
Tabori, Uri ;
Bouffet, Eric .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (29) :3537-+