Monoclonal gammopathy of undetermined significance (MGUS) manifestation in CNS: a regular or chance occurrence?

被引:0
作者
Prakhova, Lidiia [1 ]
Lebedev, Valeriy [1 ]
Ilves, Aleksandr [1 ]
Nazinkina, Yulia [1 ]
机构
[1] Russian Acad Sci, NP Bechtereva Inst Human Brain, St Petersburg, Russia
关键词
monoclonal gammopathy of undetermined significance associated neuropathy; haematology (incl blood transfusion); neurology; monoclonal gammopathy of undetermined significance; central nervous system; RENAL SIGNIFICANCE;
D O I
10.1136/bcr-2020-237726
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Monoclonal gammopathy of undetermined significance (MGUS)-associated involvement of the peripheral nervous system is widely reported in the literature. At the same time, involvement of central nervous system (CNS) occurs far less frequently. Analysing the reported cases, almost all the authors pose the question whether there is a relationship between CNS involvement and MGUS, and at what stage it is necessary to begin therapy of haematological disorders. The limited number of reported cases precludes us from getting a definite answer to these questions, thus making further accumulation of clinical data highly relevant. In this article, we present two cases of CNS involvement in patients with MGUS, which, in our opinion, may suggest the existence of a causal relationship between MGUS and CNS involvement. Currently, the above hypothesis cannot be taken as proved due to the lack of a sufficient number of clinical observations and scientific studies. Therefore, the issue of MGUS-associated CNS involvement requires further research.
引用
收藏
页数:5
相关论文
共 11 条
[1]   Management of paraproteinaemia [J].
Cook, Lucy ;
Macdonald, Donald H. C. .
POSTGRADUATE MEDICAL JOURNAL, 2007, 83 (978) :217-223
[2]   Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications [J].
Fermand, Jean-Paul ;
Bridoux, Frank ;
Dispenzieri, Angela ;
Jaccard, Arnaud ;
Kyle, Robert A. ;
Leung, Nelson ;
Merlini, Giampaolo .
BLOOD, 2018, 132 (14) :1478-1485
[3]   How I treat monoclonal gammopathy of renal significance (MGRS) [J].
Fermand, Jean-Paul ;
Bridoux, Frank ;
Kyle, Robert A. ;
Kastritis, Efstathios ;
Weiss, Brendan M. ;
Cook, Mark A. ;
Drayson, Mark T. ;
Dispenzieri, Angela ;
Leung, Nelson .
BLOOD, 2013, 122 (22) :3583-3590
[4]  
Galie E, 2013, WORLD J NEUROSCI, V03, P282, DOI [10.4236/wjns.2013.34038, DOI 10.4236/WJNS.2013.34038]
[5]   CNS demyelination in monoclonal gammopathy of undetermined significance (MGUS): Possible cause of a dementia syndrome [J].
Hampel, H ;
Schneider, C ;
Hock, C ;
MullerSpahn, F ;
Ackenheil, M .
EUROPEAN PSYCHIATRY, 1996, 11 (01) :46-49
[6]   Longitudinal extensive transverse myelitis with an abnormal uFLC ratio in a pediatric patient: Case report and literature review [J].
Hsu, Po-Chang ;
Chen, Shyi-Jou .
MEDICINE, 2017, 96 (52)
[7]   Monoclonal gammopathy of undetermined significance: A primary care guide [J].
Khouri, Jack ;
Samaras, Christy ;
Valent, Jason ;
Garcia, Alex Mejia ;
Faiman, Beth ;
Mathur, Saveta ;
Hamilton, Kim ;
Nakashima, Megan ;
Kalaycio, Matt .
CLEVELAND CLINIC JOURNAL OF MEDICINE, 2019, 86 (01) :39-46
[8]   Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management [J].
Kyle, R. A. ;
Durie, B. G. M. ;
Rajkumar, S. V. ;
Landgren, O. ;
Blade, J. ;
Merlini, G. ;
Kroeger, N. ;
Einsele, H. ;
Vesole, D. H. ;
Dimopoulos, M. ;
San Miguel, J. ;
Avet-Loiseau, H. ;
Hajek, R. ;
Chen, W. M. ;
Anderson, K. C. ;
Ludwig, H. ;
Sonneveld, P. ;
Pavlovsky, S. ;
Palumbo, A. ;
Richardson, P. G. ;
Barlogie, B. ;
Greipp, P. ;
Vescio, R. ;
Turesson, I. ;
Westin, J. ;
Boccadoro, M. .
LEUKEMIA, 2010, 24 (06) :1121-1127
[9]   Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant [J].
Leung, Nelson ;
Bridoux, Frank ;
Hutchison, Colin A. ;
Nasr, Samih H. ;
Cockwell, Paul ;
Fermand, Jean-Paul ;
Dispenzieri, Angela ;
Song, Kevin W. ;
Kyle, Robert A. .
BLOOD, 2012, 120 (22) :4292-4295
[10]  
Rentzos M, 2004, FUNCT NEUROL, V19, P253