X chromosome inactivation: recent advances and a look forward

被引：40

作者：

Briggs, Sharon F. ^{[1
]}

Pera, Renee A. Reijo ^{[2
,3
]}

机构：

[1] Stanford Univ, Dept Genet, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[2] Montana State Univ, Dept Cell Biol & Neurosci, Bozeman, MT 59711 USA

[3] Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59711 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 28卷

关键词：

PLURIPOTENT STEM-CELLS; NEURAL DEVELOPMENT; XIST RNA; CANCER; REACTIVATION; DERIVATION; RESPONSES; ANTISENSE; DISEASE; BREAST;

D O I：

10.1016/j.gde.2014.09.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic cells of female mammals, has revealed important advances in our understanding of development, epigenetic control, and RNA biology. Most of this knowledge comes from extensive studies in the mouse; however, there are some significant differences when compared to human biology. This is especially true in pluripotent cell types and, over the past few years, a significant amount of work has been dedicated to understanding these differences. This review focuses specifically on recent advances in the mechanism of Xist spreading, the role of Xist in cancer, the effects of reprogramming on X chromosome inactivation in human induced pluripotent stem cells, and new tools for studying X chromosome inactivation.

引用

页码：78 / 82

页数：5

共 39 条

[1] X inactivation and disease [J].

Agrelo, Ruben ;

Wutz, Anton .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2010, 21 (02) :194-200

[2] Molecular Signatures of Human Induced Pluripotent Stem Cells Highlight Sex Differences and Cancer Genes [J].

Anguera, Montserrat C. ;

Sadreyev, Ruslan ;

Zhang, Zhaoqing ;

Szanto, Attila ;

Payer, Bernhard ;

Sheridan, Steven D. ;

Kwok, Showming ;

Haggarty, Stephen J. ;

Sur, Mriganka ;

Alvarez, Jason ;

Gimelbrant, Alexander ;

Mitalipova, Maisam ;

Kirby, James E. ;

Lee, Jeannie T. .

CELL STEM CELL, 2012, 11 (01) :75-90

[3] Reactivation of Dyen chromosome upon reprogramming leads to changes in the replication pattern and 5hmC accumulation [J].

Bogomazova, Alexandra N. ;

Lagarkova, Maria A. ;

Panova, Alexandra V. ;

Nekrasov, Evgueny D. ;

Kiselev, Sergey L. .

CHROMOSOMA, 2014, 123 (1-2) :117-128

[4] Meta-analysis of the heterogeneity of X chromosome inactivation in human pluripotent stem cells [J].

Bruck, Tal ;

Benvenisty, Nissim .

STEM CELL RESEARCH, 2011, 6 (02) :187-193

[5] CTCF, a candidate trans-acting factor for X-inactivation choice [J].

Chao, W ;

Huynh, KD ;

Spencer, RJ ;

Davidow, LS ;

Lee, JT .

SCIENCE, 2002, 295 (5553) :345-347

[6] Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome [J].

da Rocha, Simao Teixeira ;

Boeva, Valentina ;

Escamilla-Del-Arenal, Martin ;

Ancelin, Katia ;

Granier, Camille ;

Matias, Neuza Reis ;

Sanulli, Serena ;

Chow, Jen ;

Schulz, Edda ;

Picard, Christel ;

Kaneko, Syuzo ;

Helin, Kristian ;

Reinberg, Danny ;

Stewart, A. Francis ;

Wutz, Anton ;

Margueron, Raphael ;

Heard, Edith .

MOLECULAR CELL, 2014, 53 (02) :301-316

[7] The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome [J].

Engreitz, Jesse M. ;

Pandya-Jones, Amy ;

McDonel, Patrick ;

Shishkin, Alexander ;

Sirokman, Klara ;

Surka, Christine ;

Kadri, Sabah ;

Xing, Jeffrey ;

Goren, Alon ;

Lander, Eric S. ;

Plath, Kathrin ;

Guttman, Mitchell .

SCIENCE, 2013, 341 (6147) :767-+

[8] Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells [J].

Enver, T ;

Soneji, S ;

Joshi, C ;

Brown, J ;

Iborra, F ;

Orntoft, T ;

Thykjaer, T ;

Maltby, E ;

Smith, K ;

Abu Dawud, R ;

Jones, M ;

Matin, M ;

Gokhale, P ;

Draper, J ;

Andrews, PW .

HUMAN MOLECULAR GENETICS, 2005, 14 (21) :3129-3140

[9] Derivation of novel human ground state naive pluripotent stem cells [J].

Gafni, Ohad ;

Weinberger, Leehee ;

Mansour, Abed AlFatah ;

Manor, Yair S. ;

Chomsky, Elad ;

Ben-Yosef, Dalit ;

Kalma, Yael ;

Viukov, Sergey ;

Maza, Itay ;

Zviran, Asaf ;

Rais, Yoach ;

Shipony, Zohar ;

Mukamel, Zohar ;

Krupalnik, Vladislav ;

Zerbib, Mirie ;

Geula, Shay ;

Caspi, Inbal ;

Schneir, Dan ;

Shwartz, Tamar ;

Gilad, Shlomit ;

Amann-Zalcenstein, Daniela ;

Benjamin, Sima ;

Amit, Ido ;

Tanay, Amos ;

Massarwa, Rada ;

Novershtern, Noa ;

Hanna, Jacob H. .

NATURE, 2013, 504 (7479) :282-+

[10] Klf4 reverts developmentally programmed restriction of ground state pluripotency [J].

Guo, Ge ;

Yang, Jian ;

Nichols, Jennifer ;

Hall, John Simon ;

Eyres, Isobel ;

Mansfield, William ;

Smith, Austin .

DEVELOPMENT, 2009, 136 (07) :1063-1069

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