T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3

被引：400
作者：
Hwang, ES
Szabo, SJ
Schwartzberg, PL
Glimcher, LH
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[3] NHGRI, NIH, Bethesda, MD 20892 USA
来源：
SCIENCE | 2005年 / 307卷 / 5708期
关键词：
D O I：
10.1126/science.1103336
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cell Lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell.
引用
收藏
页码：430 / 433
页数：4
相关论文
共 23 条
  • [1] Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
    Bunnell, SC
    Diehn, M
    Yaffe, MB
    Findell, PR
    Cantley, LC
    Berg, LJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (03) : 2219 - 2230
  • [2] Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Finotto, S
    Neurath, MF
    Glickman, JN
    Qin, SX
    Lehr, HA
    Green, FHY
    Ackerman, K
    Haley, K
    Gatte, PR
    Szabo, SJ
    Drazen, JM
    De Sanctis, GT
    Glimcher, LH
    [J]. SCIENCE, 2002, 295 (5553) : 336 - 338
  • [3] Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells
    Fowell, DJ
    Shinkai, K
    Liao, XC
    Beebe, AM
    Coffman, RL
    Littman, DR
    Locksley, RM
    [J]. IMMUNITY, 1999, 11 (04) : 399 - 409
  • [4] HWANG ES, UNPUB
  • [5] RECRUITMENT OF HEPATOCYTE NUCLEAR FACTOR 4 INTO SPECIFIC INTRANUCLEAR COMPARTMENTS DEPENDS ON TYROSINE PHOSPHORYLATION THAT AFFECTS ITS DNA-BINDING AND TRANSACTIVATION POTENTIAL
    KTISTAKI, E
    KTISTAKIS, NT
    PAPADOGEORGAKI, E
    TALIANIDIS, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (21) : 9876 - 9880
  • [6] The role of Tec family kinases in T cell development and function
    Lucas, JA
    Miller, AT
    Atherly, LO
    Berg, LJ
    [J]. IMMUNOLOGICAL REVIEWS, 2003, 191 (01) : 119 - 138
  • [7] Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK
    Mueller, C
    August, A
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (10) : 5056 - 5063
  • [8] Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction
    Mullen, AC
    Hutchins, AS
    High, FA
    Lee, HW
    Sykes, KJ
    Chodosh, LA
    Reiner, SL
    [J]. NATURE IMMUNOLOGY, 2002, 3 (07) : 652 - 658
  • [9] Regulation of TFII-I activity by phosphorylation
    Novina, CD
    Cheriyath, V
    Roy, AL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) : 33443 - 33448
  • [10] Tpit determines alternate fates during pituitary cell differentiation
    Pulichino, AM
    Vallette-Kasic, S
    Tsai, JPY
    Couture, C
    Gauthier, Y
    Drouin, J
    [J]. GENES & DEVELOPMENT, 2003, 17 (06) : 738 - 747
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