T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3

被引：401
|
作者：
Hwang, ES
Szabo, SJ
Schwartzberg, PL
Glimcher, LH
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[3] NHGRI, NIH, Bethesda, MD 20892 USA
来源：
SCIENCE | 2005年 / 307卷 / 5708期
关键词：
D O I：
10.1126/science.1103336
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cell Lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell.
引用
收藏
页码：430 / 433
页数：4
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