Diets Rich in Polyunsaturated Fatty Acids With Different Omega-6/Omega-3 Ratio Decrease Liver Content of Saturated Fatty Acids Across Generations of Wistar Rats

被引：4
作者：
Halfen, Simone [1 ]
Jacometo, Carolina Bespalhok [1 ]
Mattei, Patricia [1 ]
Fenstenseifer, Samanta Regine [1 ]
Machado Pfeifer, Luiz Francisco [2 ]
Burkert Del Pino, Francisco Augusto [1 ]
Ziemann Santos, Marco Aurelio [3 ]
Pereira de Pereira, Claudio Martin [3 ]
Schmitt, Eduardo [1 ]
Correa, Marcio Nunes [1 ]
机构：
[1] Univ Fed Pelotas, Ctr Pesquisa Educ & Extensao Pecuaria NUPEEC, Pelotas, RS, Brazil
[2] Empresa Brasileira Pesquisa Agr Embrapa, Porto Velho, Rondonia, Brazil
[3] Univ Fed Pelotas, Inst Quim & Geociencias Pelotas, Pelotas, RS, Brazil
来源：
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2016年 / 59卷
关键词：
Alpha-linolenic acid; essential fatty acid; lipid; metabolism; nutrition; rats; ALPHA-LINOLENIC ACID; METABOLIC SYNDROME; ADIPOSE-TISSUE; FOOD-INTAKE; PREGNANCY; OMEGA-3-FATTY-ACIDS; PROFILE; PLASMA; INFLAMMATION; MECHANISMS;
D O I：
10.1590/1678-4324-2016150549
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Our study evaluated how the consumption of diets with low (LOW group - 0.4/1) or high (CON group - 13.6/1) omega-6/omega-3 ratio across generations (F1 and F2) can modulate liver fatty acid (FA) profile and blood biomarkers. Liver content of alpha-linolenic acid was higher in animals always fed with LOW diet than animals that changed from CON to LOW diet, which by your time was higher than animals always fed with CON diet. Liver saturated FA concentration decreased in both groups from F1 to F2. In conclusion, both diets were efficient in decreasing the saturated FA liver content across generations, the LOW ratio diet was more effective in reducing blood triglycerides and non-esterified fatty acids, and there was a multigenerational effect of the LOW ratio diet, improving the FA profile even when the offspring start receiving the CON diet.
引用
收藏
页数：9
相关论文
共 33 条
  • [1] BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
  • [2] Dietary balance during pregnancy is associated with fetal adiposity and fat distribution
    Blumfield, Michelle L.
    Hure, Alexis J.
    MacDonald-Wicks, Lesley K.
    Smith, Roger
    Simpson, Stephen J.
    Giles, Warwick B.
    Raubenheimer, David
    Collins, Clare E.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (05) : 1032 - 1041
  • [3] Ω3-Polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes, and reduce lipid content but do not alter glycogen metabolism in the livers of diabetic rats fed on a high fat thermolyzed diet
    de Assis, Adriano M.
    Rech, Anderson
    Longoni, Aline
    Rotta, Liane N.
    Denardin, Cristiane C.
    Pasquali, Matheus A.
    Souza, Diogo O.
    Perry, Marcos L. S.
    Moreira, Jose C.
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2012, 361 (1-2) : 151 - 160
  • [4] Diets high in monounsaturated and polyunsaturated fatty acids decrease fatty acid synthase protein levels in adipose tissue but do not alter other markers of adipose function and inflammation in diet-induced obese rats
    Enns, Jennifer E.
    Hanke, Danielle
    Park, Angela
    Zahradka, Peter
    Taylor, Carla G.
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2014, 90 (2-3): : 77 - 84
  • [5] Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients
    Farsi, Payam Farahbakhsh
    Djazayery, Abolghassem
    Eshraghian, Mohammad Reza
    Koohdani, Fariba
    Saboor-Yaraghi, Ali Akbar
    Derakhshanian, Hoda
    Zarei, Mahnaz
    Javanbakht, Mohammad Hassan
    Djalali, Mahmoud
    [J]. ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, 2014, 58 (04) : 335 - 340
  • [6] Diets rich in polyunsaturated fatty acids:: Effect on hepatic metabolism in rats
    Gaíva, MH
    Couto, RC
    Oyama, LM
    Couto, GEC
    Silveira, VLF
    Ribeiro, EB
    Nascimento, CMO
    [J]. NUTRITION, 2003, 19 (02) : 144 - 149
  • [7] Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life
    Gibson, Robert A.
    Muhlhausler, Bev
    Makrides, Maria
    [J]. MATERNAL AND CHILD NUTRITION, 2011, 7 : 17 - 26
  • [8] Fatty Acid Supply to the Human Fetus
    Haggarty, Paul
    [J]. ANNUAL REVIEW OF NUTRITION, VOL 30, 2010, 30 : 237 - 255
  • [9] A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats
    Hanke, Danielle
    Zahradka, Peter
    Mohankumar, Suresh K.
    Clark, Jaime L.
    Taylor, Carla G.
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2013, 89 (06): : 391 - 401
  • [10] Hartman L, 1973, Lab Pract, V22, P475
1234