Copper-Catalyzed One-Pot Borylative Aldolisation β-Fluoride Elimination for the Formal Addition of Acrylates to Carbonyl Moieties

被引：16

作者：

Rasson, Corentin ^{[1
]}

Stouse, Adrien ^{[1
]}

Boreux, Arnaud ^{[1
]}

Cirriez, Virginie ^{[1
]}

Riant, Olivier ^{[1
]}

机构：

[1] Catholic Univ Louvain, Inst Condensed Matter & Nanosci Mol Solids & Reac, Pl Louis Pasteur 1,Bte L4-01-02, B-1348 Louvain La Neuve, Belgium

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 37期

关键词：

borylation; homogeneous catalysis; copper; domino reactions; Morita-Baylis-Hillman reactions; BAYLIS-HILLMAN REACTION; DOMINO REACTIONS; ALDOL REACTION; ENANTIOSELECTIVE SYNTHESIS; CASCADE REACTIONS; ALPHA; BETA-UNSATURATED DIESTERS; ORGANIC-SYNTHESIS; RING-SYSTEMS; KETONES; CYCLIZATIONS;

D O I：

10.1002/chem.201802023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report the copper-catalyzed domino borylation/aldolisation of methyl 2-fluoroacrylate with carbonyl compounds followed by an elimination to give Morita-Baylis-Hillman (MBH) analogues. The optimal conditions described were shown to be compatible with a wide range of aldehydes and ketones. Unprecedented MBH adducts derived from ketones were efficiently synthesized.

引用

页码：9234 / 9237

页数：4

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