Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides

被引：409

作者：

Everson, Daniel A. ^{[1
]}

Shrestha, Ruja ^{[1
]}

Weix, Daniel J. ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 03期

关键词：

CHLORIDES; COMPLEXES; MECHANISM; DISCOVERY; BROMIDES; BIARYLS;

D O I：

10.1021/ja9093956

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct reductive cross-coupling of alkyl halides with aryl halides is described. The transformation is efficient (equimolar amounts of the starting materials are used), generally high-yielding (all but one between 55 and 88% yield), highly functional-group-tolerant [OH, NHBoc, NHCbz, Bpin, C(O)Me, CO2Et, and CN are all tolerated], and easy to perform (uses only benchtop-stable reagents, tolerates small amounts of water and oxygen, changes color when complete, and uses filtration workup). The reaction appears to avoid the formation of intermediate organomanganese species, and a synergistic effect was found when a mixture of two ligands was employed.

引用

页码：920 / +

页数：4

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