Approach to asymptomatic creatine kinase elevation

被引：130

作者：

Moghadam-Kia, Siamak ^{[1
,2
]}

Oddis, Chester V. ^{[1
]}

Aggarwal, Rohit ^{[3
]}

机构：

[1] Univ Pittsburgh, Sch Med, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA

[2] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA

[3] Univ Pittsburgh, Sch Med, Div Rheumatol & Clin Immunol, Med, Pittsburgh, PA 15261 USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2016年 / 83卷 / 01期

关键词：

HYPER-CK-EMIA; STATIN-INDUCED MYOPATHY; MUSCLE BIOPSY; IDIOPATHIC HYPERCKEMIA; PERSISTENT HYPERCKEMIA; LARGE POPULATION; RHABDOMYOLYSIS; HYPOTHYROIDISM; DYSTROPHY; MUTATION;

D O I：

10.3949/ccjm.83a.14120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

How to manage a patient who has an elevated serum creatine kinase (CK) level but no or insignificant muscle-related signs and symptoms is a clinical conundrum. The authors provide a systematic approach, including repeat testing after a period of rest, defining higher thresholds over which pursuing a diagnosis is worthwhile, and evaluating for a variety of nonneuromuscular causes. They also outline a workup for neuromuscular causes.

引用

页码：37 / 42

页数：6

共 38 条

[1] Rhabdomyolysis associated with hyperthyroidism [J].

Alshanti, M ;

Eledrisi, MS ;

Jones, E .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2001, 19 (04) :317-317

[2] Statin-induced myopathy: The two faces of Janus [J].

Arora, Rohit ;

Liebo, Max ;

Maldonado, Frank .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2006, 11 (02) :105-112

[3] Distribution of creatine kinase in the general population: Implications for statin therapy [J].

Brewster, Lizzy M. ;

Mairuhu, Gideon ;

Sturk, August ;

van Montfrans, Gert A. .

AMERICAN HEART JOURNAL, 2007, 154 (04) :655-661

[4] PERSISTENT HYPERCKEMIA - 14 PATIENTS STUDIED IN RETROSPECT [J].

BREWSTER, LM ;

DEVISSER, M .

ACTA NEUROLOGICA SCANDINAVICA, 1988, 77 (01) :60-63

[5] Familial idiopathic hyper-ck-emia: An underrecognized condition [J].

Capasso, Margherita ;

De Angelis, Maria Vittoria ;

Di Muzio, Antonio ;

Scarciolla, Oronzo ;

Pace, Marta ;

Stuppia, Liborio ;

Comi, Giacomo Pietro ;

Uncini, Antonino .

MUSCLE & NERVE, 2006, 33 (06) :760-765

[6] Mutation in the CAV3 gene causes partial caveolin-3 deficiency and hyperCKemia [J].

Carbone, I ;

Bruno, C ;

Sotgia, F ;

Bado, M ;

Broda, P ;

Masetti, E ;

Panella, A ;

Zara, F ;

Bricarelli, FD ;

Cordone, G ;

Lisanti, MP ;

Minetti, C .

NEUROLOGY, 2000, 54 (06) :1373-1376

[7] Follow-up of a large population of asymptomatic/oligosymptomatic hyperckemic subjects [J].

D'Adda, Elisabetta ;

Sciacco, Monica ;

Fruguglietti, Maria Elisa ;

Crugnola, Veronica ;

Lucchini, Valeria ;

Martinelli-Boneschi, Filippo ;

Zecca, Chiara ;

Lamperti, Costanza ;

Comi, Giacomo Pietro ;

Bresolin, Nereo ;

Moggio, Maurizio ;

Prelle, Alessandro .

JOURNAL OF NEUROLOGY, 2006, 253 (11) :1399-1403

[8]

Dabby R, 2006, ISRAEL MED ASSOC J, V8, P110

[9] Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study [J].

Duyff, RF ;

Van den Bosch, J ;

Laman, DM ;

van Loon, BJP ;

Linssen, WHJP .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2000, 68 (06) :750-755

[10] A Japanese child with asymptomatic elevation of serum creatine kinase shows PTRF-CAVIN mutation matching with congenital generalized lipodystrophy type 4 [J].

Dwianingsih, Ery Kus ;

Takeshima, Yasuhiro ;

Itoh, Kyoko ;

Yamauchi, Yumiko ;

Awano, Hiroyuki ;

Malueka, Rusdy Ghazali ;

Nishida, Atsushi ;

Ota, Mitsunori ;

Yagi, Mariko ;

Matsuo, Masafumi .

MOLECULAR GENETICS AND METABOLISM, 2010, 101 (2-3) :233-237

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