Intestinal bacterial metabolism of flavonoids and its relation to some biological activities

被引:349
作者
Kim, DH [1 ]
Jung, EA
Sohng, IS
Han, JA
Kim, TH
Han, MJ
机构
[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea
[2] Kyung Hee Univ, Dept Nutr & Food Sci, Seoul 130701, South Korea
关键词
intestinal bacterial metabolism; flavonoids; flavonoid;
D O I
10.1007/BF03216747
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Flavonoid glycosides were metabolized to phenolic acids via aglycones by human intestinal microflora producing alpha-rhamnosidase, exo-beta-glucosidase, endo-beta-glucosidase and/or beta-glucuronidase. Rutin, hesperidin, naringin and poncirin were transformed to their aglycones by the bacteria producing alpha-rhamnosidase and beta-glucosidase or endo-alpha-glucosidase, and baicalin, puerarin and daidzin were transformed to their aglycones by the bacteria producing beta-glucuronidase, C-glysosiclase and beta-glycosidase, respectively. Anti-platelet activity and cytotoxicity city of the metabolites of flavonoid glycosides by human intestinal bacteria were more effective than those of the parental compounds. 3,4-Dihvdroxyphenylacetic acid and 4-hydroxylphenylacetic acid were more effective than rutin and quercetin on anti-platelet aggregation activity. 2,4,6-Trihydroxybenzaldehyde, quercetin and ponciretin were more effective than rutin and ponciretin on the cytotoxicity for tumor cell lines. We insist that these flavonoid glycosides should be natural prodrugs.
引用
收藏
页码:17 / 23
页数:7
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