Silver-loaded carboxymethyl cellulose nonwoven sheet with controlled counterions for infected wound healing

被引:39
作者
Ohta, Seiichi [1 ,2 ,4 ]
Mitsuhashi, Kento [1 ]
Chandel, Arvind K. Singh [1 ]
Qi, Pan [1 ]
Nakamura, Noriko [2 ]
Nakamichi, Akiko [1 ]
Yoshida, Hiromi [1 ]
Yamaguchi, Gento [3 ]
Hara, Yuichi [3 ]
Sasaki, Ryo [3 ]
Fuke, Masaya [3 ]
Takai, Madoka [4 ]
Ito, Taichi [1 ,4 ]
机构
[1] Univ Tokyo, Ctr Dis Biol & Integrat Med, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Inst Engn Innovat, 2-11-16 Yayoi,Bunkyo Ku, Tokyo 1138656, Japan
[3] Asahi Kasei Corp, Biomat Business Dev Dept, Hibiya Mitsui Tower 1-1-2 Yurakucho,Chiyoda Ku, Tokyo 1000006, Japan
[4] Univ Tokyo, Dept Bioengn, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
关键词
Carboxymethyl cellulose; Counterions; Silver release; Anti-bacterial; Wound healing; Wound dressings; HYDROGELS; NANOPARTICLES; DRESSINGS; FABRICATION; SCAFFOLDS; EFFICACY;
D O I
10.1016/j.carbpol.2022.119289
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Carboxymethyl cellulose (CMC) is a promising material for moist wound healing, and silver loading onto CMC has been examined for anti-bacterial activity. In this study, we developed silver-loaded CMC nonwoven sheets with different counterions, namely sodium CMC (CMC-Na/Ag) and partially protonated CMC (CMC-H/Ag), to examine their anti-bacterial and wound-healing properties. Owing to the presence of counter protons, CMC-H/Ag showed slower water adsorption, dissolution, and Ag release than CMC-Na/Ag. In addition, CMC-H/Ag and CMCNa/Ag exhibited differences in anti-bacterial activities in shake-flask and inhibition zone tests in vitro. An in vivo experiment using a pressure ulcer mouse model with Pseudomonas aeruginosa infection showed that CMC-Na/Ag significantly accelerated wound healing compared to CMC-H/Ag and a commercially available Ag-loaded CMC nonwoven sheet, Aquacel Ag. These results suggest the importance of controlling CMC counterions and the therapeutic potential of the developed product as a wound dressing.
引用
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页数:10
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