Silver-loaded carboxymethyl cellulose nonwoven sheet with controlled counterions for infected wound healing

被引：39

作者：

Ohta, Seiichi ^{[1
,2
,4
]}

Mitsuhashi, Kento ^{[1
]}

Chandel, Arvind K. Singh ^{[1
]}

Qi, Pan ^{[1
]}

Nakamura, Noriko ^{[2
]}

Nakamichi, Akiko ^{[1
]}

Yoshida, Hiromi ^{[1
]}

Yamaguchi, Gento ^{[3
]}

Hara, Yuichi ^{[3
]}

Sasaki, Ryo ^{[3
]}

Fuke, Masaya ^{[3
]}

Takai, Madoka ^{[4
]}

Ito, Taichi ^{[1
,4
]}

机构：

[1] Univ Tokyo, Ctr Dis Biol & Integrat Med, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Inst Engn Innovat, 2-11-16 Yayoi,Bunkyo Ku, Tokyo 1138656, Japan

[3] Asahi Kasei Corp, Biomat Business Dev Dept, Hibiya Mitsui Tower 1-1-2 Yurakucho,Chiyoda Ku, Tokyo 1000006, Japan

[4] Univ Tokyo, Dept Bioengn, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan

来源：

CARBOHYDRATE POLYMERS | 2022年 / 286卷

关键词：

Carboxymethyl cellulose; Counterions; Silver release; Anti-bacterial; Wound healing; Wound dressings; HYDROGELS; NANOPARTICLES; DRESSINGS; FABRICATION; SCAFFOLDS; EFFICACY;

D O I：

10.1016/j.carbpol.2022.119289

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Carboxymethyl cellulose (CMC) is a promising material for moist wound healing, and silver loading onto CMC has been examined for anti-bacterial activity. In this study, we developed silver-loaded CMC nonwoven sheets with different counterions, namely sodium CMC (CMC-Na/Ag) and partially protonated CMC (CMC-H/Ag), to examine their anti-bacterial and wound-healing properties. Owing to the presence of counter protons, CMC-H/Ag showed slower water adsorption, dissolution, and Ag release than CMC-Na/Ag. In addition, CMC-H/Ag and CMCNa/Ag exhibited differences in anti-bacterial activities in shake-flask and inhibition zone tests in vitro. An in vivo experiment using a pressure ulcer mouse model with Pseudomonas aeruginosa infection showed that CMC-Na/Ag significantly accelerated wound healing compared to CMC-H/Ag and a commercially available Ag-loaded CMC nonwoven sheet, Aquacel Ag. These results suggest the importance of controlling CMC counterions and the therapeutic potential of the developed product as a wound dressing.

引用

页数：10

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