Mortality in patients with psoriasis. A retrospective cohort study

被引:9
作者
Masson, Walter [1 ]
Rossi, Emiliano [1 ]
Laura Galimberti, Maria [1 ]
Krauss, Juan [1 ]
Navarro Estrada, Jose [1 ]
Galimberti, Ricardo [1 ]
Cagide, Arturo [1 ]
机构
[1] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina
来源
MEDICINA CLINICA | 2017年 / 148卷 / 11期
关键词
Psoriasis; Cardiovascular risk factors; Mortality; CORONARY-ARTERY-DISEASE; DIABETES-MELLITUS; RISK; INFLAMMATION; ATHEROSCLEROSIS; PREVALENCE; SMOKING;
D O I
10.1016/j.medcli.2016.12.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and objectives: The immune and inflammatory pathways involved in psoriasis could favor the development of atherosclerosis, consequently increasing mortality. The objectives of this study were: 1) to assess the mortality of a population with psoriasis compared to a control group, and 2) to assess the prevalence of cardiovascular risk factors. Patients and method: A retrospective cohort was analyzed from a secondary database (electronic medical record). All patients with a diagnosis of psoriasis at 1-01-2010 were included in the study and compared to a control group of the same health system, selected randomly (1:1). Subjects with a history of cardiovascular disease were excluded from the study. A survival analysis was performed considering death from any cause as an event. Follow-up was extended until 30-06-2015. Results: We included 1,481 subjects with psoriasis and 1,500 controls. Prevalence of cardiovascular risk factors was higher in the group with psoriasis. The average follow-up time was 4.6 +/- 1.7 years. Mortality was higher in psoriasis patients compared to controls (15.1 vs. 9.6 events per 1,000 person-year, P < .005). Psoriasis was seen to be significantly associated with increased mortality rates compared to the control group in the univariate analysis (HR 1.58, 95% CI 1.16-2.15, P = .004) and after adjusting for cardiovascular risk factors (HR 1.48, 95% CI 1.08-2.3, P = .014). Conclusion: In this population, patients with psoriasis showed a higher prevalence for the onset of cardiovascular risk factors as well as higher mortality rates during follow-up. (C) 2016 Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码:483 / 488
页数:6
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