The Polymorphism in Aldehyde Dehydrogenase-2 Gene Is Associated with Elevated Plasma Levels of High-Sensitivity C-Reactive Protein in the Early Phase of Myocardial Infarction

被引:29
作者
Bian, Yuan [1 ,2 ,3 ]
Chen, Yu-guo [1 ]
Xu, Feng [1 ]
Xue, Li [1 ,2 ,3 ]
Ji, Wen-qing [1 ,2 ,3 ]
Zhang, Yun [2 ,3 ,4 ]
机构
[1] Shandong Univ, Qilu Hosp, Dept Emergency, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Minist Educ PR China, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China
[3] Shandong Univ, Minist Hlth PR China, Jinan 250012, Shandong, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Cardiol, Jinan 250012, Shandong, Peoples R China
关键词
aldehyde dehydrogenase-2; high-sensitivity C-reactive protein; inflammatory response; soluble CD40 ligand; acute myocardial infarction; CD40; LIGAND; CARDIOVASCULAR RISK; OXIDATIVE STRESS; INFLAMMATION; ATHEROSCLEROSIS; ADMISSION; MARKERS; ANGINA;
D O I
10.1620/tjem.221.107
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aldehyde dehydrogenase-2 (ALDH2) is a key enzyme of alcohol metabolism, catalyzing the conversion of aldehyde to acetic acid. The G-to-A polymorphism in exon 12 of the ALDH2 gene, which causes Glu-to-Lys substitution at codon 504, has been shown to be an independent risk factor for acute myocardial infarction (AMI). We investigated the possible role of the G-to-A polymorphism in the severity of the myocardial damage in the early phase of AMI by measuring plasma levels of inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP). A total of 226 Han Chinese patients with AMI were divided into two groups: subjects without A allele (GG, n = 144) and subjects with A allele (GA and AA, n = 82), and the blood samples were collected within 12 hours after the onset of AMI. The results displayed that high-density lipoprotein cholesterol (HDL-C) was higher in GG group than that in GA and AA group (p < 0.05). The body mass index (BMI) and the concentration of hs-CRP were lower in GG group than that in GA and AA group (p < 0.05). Multivariate logistic regression analysis showed that subjects with the A allele were at an increased risk for the high level of hs-CRP (> 3 mg/L) compared with those with GG genotype (OR = 4.908, 95% CI = 1.57 similar to 20.98). Thus, the A allele in ALDH2 gene is associated with the elevated plasma levels of hs-CRP after the onset of AMI, suggesting a higher susceptibility of the myocardium to ischemic injuries.
引用
收藏
页码:107 / 112
页数:6
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