共 24 条
The Polymorphism in Aldehyde Dehydrogenase-2 Gene Is Associated with Elevated Plasma Levels of High-Sensitivity C-Reactive Protein in the Early Phase of Myocardial Infarction
被引:29
作者:
Bian, Yuan
[1
,2
,3
]
Chen, Yu-guo
[1
]
Xu, Feng
[1
]
Xue, Li
[1
,2
,3
]
Ji, Wen-qing
[1
,2
,3
]
Zhang, Yun
[2
,3
,4
]
机构:
[1] Shandong Univ, Qilu Hosp, Dept Emergency, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Minist Educ PR China, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China
[3] Shandong Univ, Minist Hlth PR China, Jinan 250012, Shandong, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Cardiol, Jinan 250012, Shandong, Peoples R China
关键词:
aldehyde dehydrogenase-2;
high-sensitivity C-reactive protein;
inflammatory response;
soluble CD40 ligand;
acute myocardial infarction;
CD40;
LIGAND;
CARDIOVASCULAR RISK;
OXIDATIVE STRESS;
INFLAMMATION;
ATHEROSCLEROSIS;
ADMISSION;
MARKERS;
ANGINA;
D O I:
10.1620/tjem.221.107
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Aldehyde dehydrogenase-2 (ALDH2) is a key enzyme of alcohol metabolism, catalyzing the conversion of aldehyde to acetic acid. The G-to-A polymorphism in exon 12 of the ALDH2 gene, which causes Glu-to-Lys substitution at codon 504, has been shown to be an independent risk factor for acute myocardial infarction (AMI). We investigated the possible role of the G-to-A polymorphism in the severity of the myocardial damage in the early phase of AMI by measuring plasma levels of inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP). A total of 226 Han Chinese patients with AMI were divided into two groups: subjects without A allele (GG, n = 144) and subjects with A allele (GA and AA, n = 82), and the blood samples were collected within 12 hours after the onset of AMI. The results displayed that high-density lipoprotein cholesterol (HDL-C) was higher in GG group than that in GA and AA group (p < 0.05). The body mass index (BMI) and the concentration of hs-CRP were lower in GG group than that in GA and AA group (p < 0.05). Multivariate logistic regression analysis showed that subjects with the A allele were at an increased risk for the high level of hs-CRP (> 3 mg/L) compared with those with GG genotype (OR = 4.908, 95% CI = 1.57 similar to 20.98). Thus, the A allele in ALDH2 gene is associated with the elevated plasma levels of hs-CRP after the onset of AMI, suggesting a higher susceptibility of the myocardium to ischemic injuries.
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页码:107 / 112
页数:6
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