Solution phase synthesis of a spiro[pyrrolidine-2,3′-oxindole] library via a three component 1,3-dipolar cycloaddition reaction

被引：111

作者：

Fokas, D ^{[1
]}

Ryan, WJ ^{[1
]}

Casebier, DS ^{[1
]}

Coffen, DL ^{[1
]}

机构：

[1] ArQule Inc, Dept Chem, Medford, MA 02155 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(98)00234-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A combinatorial library of 26,500 spiro[pyrrolidine-2,3'-oxindoles] was prepared in a single-compound format by a facile intermolecular 1,3-dipolar cycloaddition. An azomethine ylide, generated by the decarboxylative condensation of an isatin 1 with an alpha-amino acid 2, was trapped by a trans-chalcone 3 to afford heterocycles of the general structure 4. The regio-and stereochemistry of a representative product was determined by single crystal X-ray structure. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2235 / 2238

页数：4

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