Systemic oxidant/antioxidant balance in human abdominal aortic aneurysm

被引：10

作者：

Mentese, Umit ^{[1
]}

Turan, Ibrahim ^{[2
]}

Usta, Sefer ^{[1
]}

Demir, Selim ^{[3
]}

Koral, Ozgur ^{[1
]}

Mentese, Seda Oztas ^{[4
]}

Cavusoglu, Ismail Gokhan ^{[5
]}

Karahan, Suleyman Caner ^{[3
]}

Alver, Ahmet ^{[3
]}

Dogan, Orhan Veli ^{[6
]}

Aykan, Ahmet Cagri ^{[7
]}

机构：

[1] Ahi Evren Chest & Cardiovasc Surg Educ & Res Hosp, Dept Cardiovasc Surg, Trabzon, Turkey

[2] Gumushane Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, Gumushane, Turkey

[3] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, Trabzon, Turkey

[4] Kanuni Teaching & Res Hosp, Dept Emergency Med, Trabzon, Turkey

[5] Ahi Evren Chest & Cardiovasc Surg Educ & Res Hosp, Dept Radiol, Trabzon, Turkey

[6] Sakarya Univ, Fac Med, Dept Cardiovasc Surg, Sakarya, Turkey

[7] Ahi Evren Chest & Cardiovasc Surg Educ & Res Hosp, Dept Cardiol, Caml St, TR-61040 Trabzon, Turkey

来源：

PERFUSION-UK | 2016年 / 31卷 / 04期

关键词：

abdominal aortic aneurysm; oxidative stress; total oxidant status; total antioxidant status; cardiovascular; OXIDATIVE STRESS; GENE-EXPRESSION; MECHANISMS;

D O I：

10.1177/0267659115598856

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p<0.001, p<0.001, respectively). There was a positive correlation between abdominal aortic diameters, serum TOS levels (r=0.592, p<0.001) and OSI values (r=0.598, p<0.001). A cut-off value of 17.68 mu mol H2O2 equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.

引用

页码：288 / 294

页数：7

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