Early Mortality Following Intracerebral Infection with the Oshima Strain of Tick-Borne Encephalitis Virus in a Mouse Model

被引：8

作者：

Hayasaka, Daisuke ^{[1
]}

Nagata, Noriyo ^{[2
]}

Hasegawa, Hideki ^{[2
]}

Sata, Tetsutaro ^{[2
]}

Takashima, Ikuo ^{[3
]}

Koike, Satoshi ^{[4
]}

机构：

[1] Nagasaki Univ, Dept Virol, Inst Trop Med, Nagasaki 8528523, Japan

[2] Natl Inst Infect Dis, Dept Pathol, Tokyo 2080011, Japan

[3] Hokkaido Univ, Grad Sch Vet Med, Publ Hlth Lab, Dept Environm Vet Sci, Sapporo, Hokkaido 0600818, Japan

[4] Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Tokyo 1568506, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2010年 / 72卷 / 04期

关键词：

central nervous system; mouse; pathogenesis; Tick-borne disease; virus infection; WEST-NILE-VIRUS; CELLS; JAPAN; IMMUNOPATHOLOGY; PATHOGENICITY; APOPTOSIS; HOKKAIDO; EUROPE; MICE; VIVO;

D O I：

10.1292/jvms.09-0258

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes acute central nervous system (CNS) disease in humans. In this study, we examined the pathogenic process following intracerebral infection with the Oshima strain of TBEV in a mouse model. Intracerebral infection resulted in dose-dependent mortality, and all mice died following challenge with 10(2) PFU or more of the virus within 10 days. Acutely necrotic neurons and widespread inflammation were observed throughout the CNS. We therefore conclude that mortality following intracerebral infection results from a direct CNS pathology.

引用

页码：391 / 396

页数：6

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