Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

被引：51

作者：

Smith, Steven J. ^{[1
]}

Zhao, Xue Zhi ^{[2
]}

Passos, Dario Oliveira ^{[3
]}

Lyumkis, Dmitry ^{[3
,4
]}

Burke, Terrence R., Jr. ^{[2
]}

Hughes, Stephen H. ^{[1
]}

机构：

[1] NCI, HIV Dynam & Replicat Program, Ctr Canc Res, Frederick, MD 21702 USA

[2] NCI, Chem Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA

[3] Salk Inst Biol Studies, Lab Genet, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 02期

关键词：

HIV; integration; INSTIs; drug resistance; antiviral therapy;

D O I：

10.3390/v13020205

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation INSTIs are effective but can select for resistant viruses. Recent advances have led to several potent second-generation INSTIs that are effective against both wild-type (WT) HIV-1 integrase and many of the first-generation INSTI-resistant mutants. The emergence of resistance to these new second-generation INSTIs has been minimal, which has resulted in alternative treatment strategies for HIV-1 patients. Moreover, because of their high antiviral potencies and, in some cases, their bioavailability profiles, INSTIs will probably have prominent roles in pre-exposure prophylaxis (PrEP). Herein, we review the current state of the clinically relevant INSTIs and discuss the future outlook for this class of antiretrovirals.

引用

页数：28

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