siRNA delivery into human T cells and primary cells with carbon-nanotube transporters

被引：503

作者：

Liu, Zhuang

Winters, Mark

Holodniy, Mark

Dai, Hongjie ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Div Infect Dis, Stanford, CA 94305 USA

[3] Palo Alto Hlth Care Syst, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 12期

关键词：

carbon nanotubes; drug delivery; nanobiotechnology; RNA interference; T cells;

D O I：

10.1002/anie.200604295

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Special delivery: Functionalized single-walled nanotubes (SWNT) can be used as molecular transporters to shuttle short interfering RNA (siRNA) into human T cells and primary cells and silence the expression of HIV-specific cell-surface receptors and coreceptors (see picture; scale bars 40 μm). This silencing effect, known to block HIV viral entry and reduce infection, is superior to that observed with conventional liposome-based nonviral delivery agents. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2023 / 2027

页数：5

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