Pseudogene PTENP1 Suppresses Gastric Cancer Progression by Modulating PTEN

被引：55

作者：

Guo, Xiaoqiang ^{[1
,2
]}

Deng, Li ^{[3
]}

Deng, Kaiyuan ^{[1
,2
]}

Wang, Hao ^{[1
,2
]}

Shan, Ting ^{[1
,2
]}

Zhou, Hong ^{[1
,2
]}

Liang, Zheng ^{[1
,2
]}

Xia, Jiazeng ^{[1
,2
]}

Li, Chenglong ^{[4
]}

机构：

[1] Nanjing Med Univ, Dept Gen Surg, Wuxi Hosp 2, Wuxi 214002, Peoples R China

[2] Nanjing Med Univ, Translat Med Ctr, Wuxi Hosp 2, Wuxi 214002, Peoples R China

[3] Soochow Univ, Dept Anesthesiol, Affiliated Hosp 1, Suzhou 215000, Peoples R China

[4] Soochow Univ, Dept Vasc Surg, Affiliated Hosp 2, Suzhou 215000, Peoples R China

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Gastric cancer; long non-coding RNA; pseudogene; PTENP1; PTEN; tumor suppressor; LONG NONCODING RNA; PROLIFERATION; APOPTOSIS; GENE; EXPRESSION; INVASION; CELLS; GAS5; MEG3;

D O I：

10.2174/1871520615666150507121407

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PTENP1 has been demonstrated to function as a tumor suppressor in several cancer cells. However, its expression and biological roles in gastric cancer (GC) have not yet been investigated. In this study, we demonstrated that PTENP1 was frequently decreased in GC tissues and cell lines, which might be partly associated with DNA hypermethylation, and lower PTENP1 expression was associated with larger tumor size, more advanced stage, deeper invasion depth and lymphatic metastasis. In addition, our data suggested that PTENP1 could regulate GC cell proliferation, apoptosis, migration and invasion in vitro. Furthermore, we demonstrated that PTENP1 could modulate the PTEN protein expression. Taken together, these results suggest that PTENP1 functions as a novel tumor suppressor in GC and its suppressive ability may be involved in the modulation of PTEN.

引用

页码：456 / 464

页数：9

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