Polycyclization Enabled by Relay Catalysis: One-Pot Manganese-Catalyzed C-H Allylation and Silver-Catalyzed Povarov Reaction

被引：57
作者：
Chen, Shi-Yong [1 ]
Li, Qingjiang [1 ,2 ]
Liu, Xu-Ge [1 ]
Wu, Jia-Qiang [1 ]
Zhang, Shang-Shi [1 ]
Wang, Honggen [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
来源：
CHEMSUSCHEM | 2017年 / 10卷 / 11期
基金：
中国国家自然科学基金;
关键词：
C-H activation; cycloaddition; manganese; relay catalysis; silver; ELECTRON-DEFICIENT ARENES; CARBON-HYDROGEN BONDS; N-TYPE REACTIONS; ROOM-TEMPERATURE; ALLYLIC ALCOHOLS; NATURAL-PRODUCTS; ACTIVATION; FUNCTIONALIZATION; ALKYLATION; BENZAMIDES;
D O I：
10.1002/cssc.201700452
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, a MnI/AgI-based relay catalysis process is described for the one-pot synthesis of polycyclic products by a formal [3+2] and [4+2] cycloaddition reaction cascade. A manganese(I) complex catalyzed the first example of directed C-H allylation with allenes, setting the stage for an in situ Povarov cyclization catalyzed by silver(I). The reaction proceeds with high bond-forming efficiency (three C-C bonds), broad substrate scope, high regio- and stereoselectivity, and 100% atom economy.
引用
收藏
页码：2360 / 2364
页数：5
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