Regulation of mRNA cap methylation

被引：158
作者：
Cowling, Victoria H. [1 ]
机构：
[1] Univ Dundee, Coll Life Sci, Div Cell Biol & Immunol, Dundee DD1 5EH, Scotland
来源：
BIOCHEMICAL JOURNAL | 2010年 / 425卷
基金：
英国医学研究理事会;
关键词：
gene regulation; mRNA cap methylation; translation; transcription; S-ADENOSYLHOMOCYSTEINE HYDROLASE; CAPPING ENZYME; POLYMERASE-II; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION ELONGATION; CONDITIONAL MUTANTS; BINDING COMPLEX; IN-VIVO; P-TEFB;
D O I：
10.1042/BJ20091352
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.
引用
收藏
页码：295 / 302
页数：8
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