Regulation of mRNA cap methylation

被引：153
作者：
Cowling, Victoria H. [1 ]
机构：
[1] Univ Dundee, Coll Life Sci, Div Cell Biol & Immunol, Dundee DD1 5EH, Scotland
来源：
BIOCHEMICAL JOURNAL | 2010年 / 425卷
基金：
英国医学研究理事会;
关键词：
gene regulation; mRNA cap methylation; translation; transcription; S-ADENOSYLHOMOCYSTEINE HYDROLASE; CAPPING ENZYME; POLYMERASE-II; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION ELONGATION; CONDITIONAL MUTANTS; BINDING COMPLEX; IN-VIVO; P-TEFB;
D O I：
10.1042/BJ20091352
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.
引用
收藏
页码：295 / 302
页数：8
相关论文
共 84 条
  • [1] Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors
    Bentley, DL
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (03) : 251 - 256
  • [2] METHYLATION-DEPENDENT TRANSLATION OF VIRAL MESSENGER-RNAS INVITRO
    BOTH, GW
    BANERJEE, AK
    SHATKIN, AJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (03) : 1189 - 1193
  • [3] Evolution of the holozoan ribosome biogenesis regulon
    Brown, Seth J.
    Cole, Michael D.
    Erives, Albert J.
    [J]. BMC GENOMICS, 2008, 9 (1)
  • [4] Molecular evolution of the RNA polymerase IICTD
    Chapman, Rob D.
    Haidemann, Martin
    Hintermair, Corinna
    Eick, Dirk
    [J]. TRENDS IN GENETICS, 2008, 24 (06) : 289 - 296
  • [5] S-adenosylmethionine and methylation
    Chiang, PK
    Gordon, RK
    Tal, J
    Zeng, GC
    Doctor, BP
    Pardhasaradhi, K
    McCann, PP
    [J]. FASEB JOURNAL, 1996, 10 (04) : 471 - 480
  • [6] Apoptosis and autophagy induction in mammalian cells by small interfering RNA knockdown of mRNA capping enzymes
    Chu, Chun
    Shatkin, Aaron J.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (19) : 5829 - 5836
  • [7] Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors
    Cole, M. D.
    Cowling, V. H.
    [J]. ONCOGENE, 2009, 28 (09) : 1169 - 1175
  • [8] Transcription-independent functions of MYC: regulation of translation and DNA replication
    Cole, Michael D.
    Cowling, Victoria H.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (10) : 810 - 815
  • [9] The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20 the small subunit of the nuclear cap-binding complex
    Colot, HV
    Stutz, F
    Rosbash, M
    [J]. GENES & DEVELOPMENT, 1996, 10 (13) : 1699 - 1708
  • [10] The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding
    Cowling, Victoria H.
    Cole, Michael D.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (06) : 2059 - 2073
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