The Three-Dimensional Structure of Mimivirus

被引：46

作者：

Klose, Thomas ^{[1
]}

Kuznetsov, Yurii G. ^{[2
]}

Xiao, Chuan ^{[3
]}

Sun, Siyang ^{[1
]}

McPherson, Alexander ^{[2
]}

Rossmann, Michael G. ^{[1
]}

机构：

[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

[2] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92717 USA

[3] Univ Texas El Paso, Dept Chem, El Paso, TX 79968 USA

来源：

INTERVIROLOGY | 2010年 / 53卷 / 05期

关键词：

Atomic force microscopy; Cryo-electron microscopy; Mimivirus; three-dimensional structure; Nucleocytoplasmic large DNA viruses; GIANT MIMIVIRUS; VIRUS; EVOLUTION; SEQUENCE; PROTEIN;

D O I：

10.1159/000312911

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mimivirus, the prototypic member of the new family of Mimiviridae, is the largest virus known to date. Progress has been made recently in determining the three-dimensional structure of the 0.75-mu m diameter virion using cryo-electron microscopy and atomic force microscopy. These showed that the virus is composed of an outer layer of dense fibers surrounding an icosahedrally shaped capsid and an internal membrane sac enveloping the genomic material of the virus. Additionally, a unique starfish-like structure at one of the fivefold vertices, required by the virus for infecting its host, has been defined in more detail. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：268 / 273

页数：6

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