Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

被引：36

作者：

Wang, Y. -J. ^{[1
]}

Lin, E. -T. ^{[2
]}

Chen, Y. -T. ^{[3
,4
]}

Chiu, P. -C. ^{[5
]}

Lin, B. -S. ^{[6
]}

Chiang, H. -M. ^{[7
,8
]}

Huang, Y. -H. ^{[9
]}

Wang, K. -Y. ^{[7
,8
]}

Lin, H. -Y. ^{[10
,11
]}

Chang, T. -M. ^{[10
,11
]}

Chang, C. -C. ^{[2
,6
,7
,8
,12
]}

机构：

[1] MacKay Mem Hosp, Dept Dermatol, Taipei, Taiwan

[2] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan

[3] Taipei Med Univ, Shuang Ho Hosp, Dept Dermatol, Taipei, Taiwan

[4] Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth, Taipei, Taiwan

[5] Aletheia Holist Dermatol Ctr, Taichung, Taiwan

[6] Natl Chiao Tung Univ, Inst Imaging & Biomed Photon, Tainan, Taiwan

[7] China Med Univ Hosp, Dept Cosmeceut, Taichung, Taiwan

[8] China Med Univ Hosp, Grad Inst Cosmeceut, Taichung, Taiwan

[9] Yung Hsueh Huang Dermatol Clin, Changhua, Taiwan

[10] Hung Kuang Univ, Dept Appl Cosmetol, Taichung, Taiwan

[11] Hung Kuang Univ, Masters Program Cosmet Sci, Taichung, Taiwan

[12] China Med Univ Hosp, Aesthet Med Ctr, Taichung, Taiwan

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2020年 / 34卷 / 03期

关键词：

1,064 NM LASER; 755NM PICOSECOND; RETINOIC ACID; SKIN; NDYAG; LIGHT; VI;

D O I：

10.1111/jdv.15934

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Recent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been identified to be effective for improving photoaging conditions. Objective We aimed to compare the efficacy and tolerance of the picosecond alexandrite laser with those of DLA and TCC in female Asian patients with melasma. Methods Twenty-nine patients were randomly assigned to group A1 (3 laser sessions at 4-week intervals), A2 (5 laser sessions at 4-week intervals) or B (TCC daily for at least 8 weeks and then tapered until the final evaluation). The Melasma Area, Severity Index (MASI) score and VISIA were assessed at baseline, week 12 and week 20. By week 20, the follow-up periods for groups A1 and A2 were 3 months and 1 month, respectively. Results Nine, 11 and 6 participants in groups A1, A2 and B completed the study, respectively. MASI scores were significantly improved in all 3 groups at weeks 12 and 20. In groups A1, A2 and B, the improvement rates at week 20 were 53%, 38% and 50%, respectively. VISIA analysis additionally revealed a significant improvement in spots, porphyria, pores and brown spots after 3 laser sessions (P < 0.05). Group A2 showed greater improvements than group A1 in terms of spots, wrinkles and pores; however, only red areas were significantly different (P < 0.001). All side-effects in the 3 groups were transient and gradually subsided after 1-3 months. Conclusion Picosecond alexandrite laser treatment using DLA showed comparable efficacy with TCC for the treatment of melasma. Improvements in texture, spots, wrinkles and pores were observed in the laser groups. Patients with melasma lesions that exhibit telangiectasia may benefit from additional laser treatment sessions.

引用

页码：624 / 632

页数：9

共 31 条

[1] Use of a Picosecond Pulse Duration Laser With Specialized Optic for Treatment of Facial Acne Scarring [J].