Relationship between white blood cell count and components of metabolic syndrome among young adolescents

被引：21

作者：

Wu, Chung-Ze ^{[2
]}

Hsiao, Fone-Ching ^{[3
]}

Lin, Juinn-Diann ^{[4
]}

Su, Ching-Chieh ^{[1
]}

Wang, Kwo-Syin ^{[5
]}

Chu, Yi-Min ^{[6
]}

Lee, Li-Hsiu ^{[6
]}

Wang, Kun ^{[1
]}

Hsia, Te-Lin ^{[1
]}

Pei, Dee ^{[1
]}

机构：

[1] Fu Jen Catholic Univ, Coll Med, Sch Med, Dept Internal Med,Cardinal Tien Hosp, Xindian 23137, Taipei County, Taiwan

[2] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

[3] Tri Serv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

[4] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

[5] Lotung St Marys Hosp, Dept Crit Med, Yi Lang, Taiwan

[6] Fu Jen Catholic Univ, Coll Med, Sch Med, Dept Med Technol,Cardinal Tien Hosp, Taipei, Taiwan

来源：

ACTA DIABETOLOGICA | 2010年 / 47卷 / 01期

关键词：

White blood cell count; Metabolic syndrome; Young adolescents; Body mass index; Triglyceride; BODY-MASS INDEX; NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; C-REACTIVE PROTEIN; TYPE-2; DIABETES-MELLITUS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE; SEXUAL-MATURATION; LEUKOCYTE COUNT;

D O I：

10.1007/s00592-009-0101-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Components of metabolic syndrome (MetS) have been associated with several inflammatory factors, including white blood cell count (WBCC). In the present study, the relationships between WBCC and aspects of MetS in young adolescents were investigated. We enrolled 596 participants (328 males and 268 females) from 10 to 13 years of age and with normal WBCC in this study. They were divided into four quartiles according to WBCC (WBCC1-4, from lowest to highest WBCC). The mean values of MetS components for each group were compared in males and females separately. Multivariate linear regression analysis between the WBCC and the components of MetS after adjusted for age and body mass index (BMI) were also evaluated. In the male group, the BMI of WBCC1 and WBCC2 was significantly lower than WBCC4. The total cholesterol and low-density lipoprotein-cholesterol (LDL-C) of WBCC2 were significantly higher than WBCC1 and WBCC4. Triglyceride (TG) levels of WBCC1 were significantly lower than WBCC3 and WBCC4, and TG levels of WBCC2 were significantly lower than WBCC4. Alternatively, the BMI of WBCC1 and WBCC2 were significantly lower than WBCC3 in the female group. Finally, the TG and fasting plasma glucose (FPG) levels of WBCC1 were significantly lower than WBCC3 or WBCC4, respectively. After multivariate linear regression, WBCC was positively correlated to BMI and TG, but negatively correlated to FPG in males whereas in young adolescent females, WBCC was positively correlated to BMI and FPG. In conclusion BMI was positively correlated with WBCC in young adolescent females and males. Thus, BMI is the most important component of MetS in this age group. In addition, TG levels in males and FPG in females were significantly related to WBCC. These findings could be regarded an early indication for the future development of full-blown MetS or cardiovascular diseases.

引用

页码：65 / 71

页数：7

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