Gender effect on apolipoprotein E ε4 allele-associated risk for sporadic Alzheimer's disease

被引：0

作者：

Combarros, O ^{[1
]}

Leno, C

Oterino, A

Berciano, J

Fernandez-Luna, JL

Fernandez-Viadero, C

Pena, N

Miro, J

Delgado, M

机构：

[1] Univ Hosp Marques de Valdecilla, Serv Neurol, Santander 39008, Spain

[2] Univ Hosp Marques de Valdecilla, Serv Immunol, Santander 39008, Spain

[3] Geriatr Hosp Padre Menni, Cueto, Spain

[4] Ctr Community Hlth, Astillero, Spain

[5] Univ Cantabria, Fac Med, Dept Prevent Med & Publ Hlth, E-39005 Santander, Spain

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1998年 / 97卷 / 01期

关键词：

Alzheimer's disease; apolipoprotein E; risk factor; sex;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction - The role of gender in Alzheimer's disease (AD), and its possible interaction with apolipoprotein E (apoE). has been controversial, Material and methods - ApoE allelic frequencies and the effect of apoE epsilon 4 allele dosage on risk and age at onset of AD were evaluated, separately for men and women. in 100 patients with sporadic AD and 100 age-matched controls. Results - The distribution of apoE alleles and the odds ratio for AD, when associated with 1 or 2 epsilon 4 alleles were not statistically different between men and women, No effect of the dosage of the epsilon 4 allele was found on the age at onset of dementia in the 2 sex groups Conclusion - Our data suggest that the relation of the apoE genotype to AD is not dependent on sex.

引用

页码：68 / 71

页数：4

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