Xanthine based N-heterocyclic carbene (NHC) complexes

被引：57

作者：

Valdes, Hugo ^{[1
]}

Canseco-Gonzalez, Daniel ^{[2
,3
]}

German-Acacio, Juan Manuel ^{[4
]}

Morales-Morales, David ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Circuito Exterior S-N,Ciudad Univ, Mexico City 04510, DF, Mexico

[2] Univ Autonoma Chapingo, Lab Nacl Invest, CONACYT, Texcoco De Mora, Mexico

[3] Univ Autonoma Chapingo, Serv Agroalimentario & Forestal, Texcoco De Mora, Mexico

[4] Univ Nacl Autonoma Mexico CIC UNAM, Inst Nacl Ciencias Med & Nutr SZ, Red Apoyo Invest, Mexico City 14000, DF, Mexico

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2018年 / 867卷

关键词：

N-heterocyclic carbene; Xanthine; Caffeine; Theobromine; Theophylline; Cancer; Catalysis; Metallodrug; CAFFEINE; THEOPHYLLINE;

D O I：

10.1016/j.jorganchem.2018.01.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

N-heterocyclic carbene (NHC) complexes derived from xanthines have attracted much attention. Xanthines comprise a wide range of compounds, among which the best known are caffeine, theophylline and theobromine. Xanthine-NHC complexes have been used as catalysts, antimicrobial, anticancer agents and for their photoluminescent properties. The easy functionalization of xanthines along with their biological activity makes their metal derivatives excellent candidates for the development of novel metallodrugs. And depending of the metal other xanthine-NHC complexes are excellent catalysts for different important organic transformations. Thus, in this review, we summarized the synthesis and applications that xanthine-NHC metal complexes have found this far. (c) 2018 Elsevier B.V. All rights reserved.

引用

页码：51 / 54

页数：4

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