Sesquiterpene lactones from Artemisia mongolica

被引：12

作者：

Zhu, Ziwei ^{[1
,2
,3
]}

Turak, Ablajan ^{[1
,2
]}

Aisa, Haji Akber ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China

[2] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 199卷

基金：

对外科技合作项目（国际科技项目）; 中国国家自然科学基金;

关键词：

Artemisia mongolica; Asteraceae; Sesquiterpene lactones; Single-crystal X-ray analysis; Anti-inflammatory; Antitumor;

D O I：

10.1016/j.phytochem.2022.113158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve undescribed sesquiterpene lactones and seven known sesquiterpene lactones were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data. The absolute configurations of mongolicolide A (1), mongolicolide C (3), 1R, 3S-Dihydroxy-7S, 11R-germacra-4Z.9Z-dien-12, 6S-olide (5), indicumolide E (9), indicumolide F (10), and indicumolide G (11) were determined by single-crystal X-ray crystallography. The X-ray crystal structure of artabsinolide E (15) was reported for the first time. In addition, beibersteneolide-B (13) showed moderate anti-inflammatory activity and marked antitumor activity, artemyriantholide E (18) show moderate antitumor activity.

引用

页数：10

共 19 条

[1] STRUCTURES OF THE ARTABSINOLIDES - PHOTO-OXYGENATION STUDIES ON ARTABSIN [J].

BEAUHAIRE, J ;

FOURREY, JL .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (03) :861-864

[2] Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera [J].

Chen, Qi-Bin ;

Xin, Xue-Lei ;

Yang, Yi ;

Lee, Shoei-Sheng ;

Aisa, H. A. .

JOURNAL OF NATURAL PRODUCTS, 2014, 77 (04) :807-812

[3] Anti HSV-1 Flavonoid Derivatives Tethered with Houttuynin from Houttuynia cordata [J].

Chen, Shao-Dan ;

Li, Ting ;

Gao, Hao ;

Zhu, Qin-Chang ;

Lu, Chuan-Jian ;

Wu, Hong-Ling ;

Peng, Tao ;

Yao, Xin-Sheng .

PLANTA MEDICA, 2013, 79 (18) :1742-1748

[4]

[董岩 Dong Yan], 2013, [中国药学杂志, Chinese Pharmaceutical Journal], V48, P1359

[5] Three New Sesquiterpenoids from Chrysanthemum indicum L. [J].

Feng, Zi-Ming ;

Song, Shuang ;

Xia, Peng-Fei ;

Jiang, Jian-Shuang ;

Zhang, Pei-Cheng .

HELVETICA CHIMICA ACTA, 2009, 92 (09) :1823-1828

[6]

Howiriny Tawfeq A Al, 2005, IND J CHEM B B, V44, P2538

[7]

Hu J.F., 1998, Nat. Prod. Res. Dev., V11, P95, DOI DOI 10.16333/J.1001-6880.1999.04.020

[8] New guaianolides from Artemisia anomala [J].

Hu, Ze-Hua ;

Zhang, Peng ;

Huang, De-Bin ;

Wu, Ji-Zhou .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2012, 14 (02) :111-114

[9] Guaianolide sesquiterpene lactones from Achillea millefolium L [J].

Li, Hongliang ;

Li, Jun ;

Liu, Mengqi ;

Xie, Rongrong ;

Zang, Yi ;

Li, Jia ;

Aisa, Haji Akber .

PHYTOCHEMISTRY, 2021, 186

[10]

Li Y., 2012, Z NATURFORSCH

← 1 2 →