Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training

被引:79
作者
Chaudhary, Ujwal [1 ]
Vlachos, Ioannis [2 ]
Zimmermann, Jonas B. [2 ]
Espinosa, Arnau [2 ]
Tonin, Alessandro [2 ,3 ]
Jaramillo-Gonzalez, Andres [3 ]
Khalili-Ardali, Majid [3 ]
Topka, Helge [4 ]
Lehmberg, Jens [5 ]
Friehs, Gerhard M. [6 ]
Woodtli, Alain [2 ]
Donoghue, John P. [7 ]
Birbaumer, Niels [3 ]
机构
[1] ALS Voice gGmbH, Mossingen, Germany
[2] Wyss Ctr Bio & Neuroengn, Geneva, Switzerland
[3] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany
[4] Munchen Klin Bogenhausen, Cognit Neurol & Stroke Unit, Dept Neurol, Clin Neurophysiol, Munich, Germany
[5] Munchen Klin Bogenhausen, Dept Neurosurg, Munich, Germany
[6] European Univ, Neurosurg Dept, Nicosia, Cyprus
[7] Brown Univ, Carney Brain Inst, Providence, RI 02912 USA
关键词
BRAIN-COMPUTER INTERFACE; COMMUNICATION; STATE; BCI; ALS;
D O I
10.1038/s41467-022-28859-8
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. While others have evaluated communication in people with remaining muscle control, to the best of our knowledge, it is not known whether neural-based communication remains possible in a completely locked-in state. Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state. The authors record neural firing rates in a patient with ALS in completely locked-in state and show that the patient can modulate neural firing rates based on auditory feedback to select letters to form words and phrases to communicate his needs and experiences.
引用
收藏
页数:9
相关论文
共 39 条
  • [1] BAUER G, 1979, J NEUROL, V221, P77, DOI 10.1007/BF00313105
  • [2] Communication Support for People with ALS
    Beukelman, David
    Fager, Susan
    Nordness, Amy
    [J]. NEUROLOGY RESEARCH INTERNATIONAL, 2011, 2011
  • [3] AAC for adults with acquired neurological conditions: A review
    Beukelman, David R.
    Fager, Susan
    Ball, Laura
    Dietz, Aimee
    [J]. AUGMENTATIVE AND ALTERNATIVE COMMUNICATION, 2007, 23 (03) : 230 - 242
  • [4] A spelling device for the paralysed
    Birbaumer, N
    Ghanayim, N
    Hinterberger, T
    Iversen, I
    Kotchoubey, B
    Kübler, A
    Perelmouter, J
    Taub, E
    Flor, H
    [J]. NATURE, 1999, 398 (6725) : 297 - 298
  • [5] Breaking the silence: Brain-computer interfaces (BCI) for communication and motor control
    Birbaumer, Niels
    [J]. PSYCHOPHYSIOLOGY, 2006, 43 (06) : 517 - 532
  • [6] Learned regulation of brain metabolism
    Birbaumer, Niels
    Ruiz, Sergio
    Sitaram, Ranganatha
    [J]. TRENDS IN COGNITIVE SCIENCES, 2013, 17 (06) : 295 - 302
  • [7] Brain-computer interfaces in the completely locked-in state and chronic stroke
    Chaudhary, U.
    Birbaumer, N.
    Ramos-Murguialday, A.
    [J]. BRAIN-COMPUTER INTERFACES: LAB EXPERIMENTS TO REAL-WORLD APPLICATIONS, 2016, 228 : 131 - 161
  • [8] Brain-Machine Interface (BMI) in paralysis
    Chaudhary, U.
    Birbaumer, N.
    Curado, M. R.
    [J]. ANNALS OF PHYSICAL AND REHABILITATION MEDICINE, 2015, 58 (01) : 9 - 13
  • [9] Chaudhary U, 2021, G NODE, DOI [10.12751/g-node.jdwmjd, DOI 10.12751/G-NODE.JDWMJD]
  • [10] Brain Computer Interfaces for Assisted Communication in Paralysis and Quality of Life
    Chaudhary, Ujwal
    Chander, Bankim Subhash
    Ohry, Avi
    Jaramillo-Gonzalez, Andres
    Lule, Dorothee
    Birbaumer, Niels
    [J]. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 2021, 31 (11)