White matter correlates of cognitive domains in normal aging with diffusion tensor imaging

被引:128
作者
Sasson, Efrat [1 ]
Doniger, Glen M. [2 ]
Pasternak, Ofer [3 ]
Tarrasch, Ricardo [4 ]
Assaf, Yaniv [1 ]
机构
[1] Tel Aviv Univ, Fac Life Sci, Dept Neurobiol, IL-69978 Tel Aviv, Israel
[2] NeuroTrax Corp, Dept Clin Sci, Bellaire, TX USA
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Psychiat,Psychiat Neuroimaging Lab, Boston, MA 02115 USA
[4] Tel Aviv Univ, Sch Educ, IL-69978 Tel Aviv, Israel
基金
以色列科学基金会;
关键词
magnetic resonance imaging; diffusion tensor imaging; executive function; information processing speed; memory; aging; white matter; temporal lobe; DISCONNECTION SYNDROMES; WORKING-MEMORY; VISUAL MEMORY; FIBER-BUNDLES; FRONTAL-LOBE; INTEGRITY; PERFORMANCE; TRACTOGRAPHY; IMPAIRMENTS; FASCICULUS;
D O I
10.3389/fnins.2013.00032
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The ability to perform complex as well as simple cognitive tasks engages a network of brain regions that is mediated by the white matter fiber bundles connecting them. Different cognitive tasks employ distinctive white matter fiber bundles. The temporal lobe and its projections subserve a variety of key functions known to deteriorate during aging. In a cohort of 52 healthy subjects (ages 25-82 years), we performed voxel-wise regression analysis correlating performance in higher-order cognitive domains (executive function, information processing speed, and memory) with white matter integrity, as measured by diffusion tensor imaging (DTI) fiber tracking in the temporal lobe projections [uncinate fasciculus (UF), fornix, cingulum, inferior longitudinal fasciculus (ILF), and superior longitudinal fasciculus (SLF)]. The fiber tracts were spatially registered and statistical parametric maps were produced to spatially localize the significant correlations. Results showed that performance in the executive function domain is correlated with DTI parameters in the left SLF and right UF; performance in the information processing speed domain is correlated with fractional anisotropy (FA) in the left cingulum, left fornix, right and left ILF and SLF; and the memory domain shows significant correlations with DTI parameters in the right fornix, right cingulum, left ILF, left SLF and right UF. These findings suggest that DTI tractography enables anatomical definition of region of interest (ROI) for correlation of behavioral parameters with diffusion indices, and functionality can be correlated with white matter integrity.
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页数:13
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