MMDB: Entrez's 3D-structure database

被引:119
作者
Chen, J [1 ]
Anderson, JB [1 ]
DeWeese-Scott, C [1 ]
Fedorova, ND [1 ]
Geer, LY [1 ]
He, SQ [1 ]
Hurwitz, DI [1 ]
Jackson, JD [1 ]
Jacobs, AR [1 ]
Lanczycki, CJ [1 ]
Liebert, CA [1 ]
Liu, CL [1 ]
Madej, T [1 ]
Marchler-Bauer, A [1 ]
Marchler, GH [1 ]
Mazumder, R [1 ]
Nikolskaya, AN [1 ]
Rao, BS [1 ]
Panchenko, AR [1 ]
Shoemaker, BA [1 ]
Simonyan, V [1 ]
Song, JS [1 ]
Thiessen, PA [1 ]
Vasudevan, S [1 ]
Wang, YL [1 ]
Yamashita, RA [1 ]
Yin, JJ [1 ]
Bryant, SH [1 ]
机构
[1] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1093/nar/gkg086
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
dimensional structures are now known within most protein families and it is likely, when searching a sequence database, that one will identify a homolog of known structure. The goal of Entrez' s 3D- structure database is to make structure information and the functional annotation it can provide easily accessible to molecular biologists. To this end, Entrez' s search engine provides several powerful features: ( i) links between databases, for example between a protein s sequence and structure; ( ii) precomputed sequence and structure neighbors; and ( iii) structure and sequence/ structure alignment visualization. Here, we focus on a new feature of Entrez' s Molecular Modeling Database ( MMDB) : Graphical summaries of the biological annotation available for each 3D structure, based on the results of automated comparative analysis. MMDB is available at: http: / / www. ncbi. nlm. nih. gov/ Entrez/ structure. html.
引用
收藏
页码:474 / 477
页数:4
相关论文
共 13 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]   Urkinase: Structure of acetate kinase, a member of the ASKHA superfamily of phosphotransferases [J].
Buss, KA ;
Cooper, DR ;
Ingram-Smith, C ;
Ferry, JG ;
Sanders, DA ;
Hasson, MS .
JOURNAL OF BACTERIOLOGY, 2001, 183 (02) :680-686
[3]   Surprising similarities in structure comparison [J].
Gibrat, JF ;
Madej, T ;
Bryant, SH .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (03) :377-385
[4]   CDD: a curated Entrez database of conserved domain alignments [J].
Marchler-Bauer, A ;
Anderson, JB ;
DeWeese-Scott, C ;
Fedorova, ND ;
Geer, LY ;
He, SQ ;
Hurwitz, DI ;
Jackson, JD ;
Jacobs, AR ;
Lanczycki, CJ ;
Liebert, CA ;
Liu, CL ;
Madej, T ;
Marchler, GH ;
Mazumder, R ;
Nikolskaya, AN ;
Panchenko, AR ;
Rao, BS ;
Shoemaker, BA ;
Simonyan, V ;
Song, JS ;
Thiessen, PA ;
Vasudevan, S ;
Wang, YL ;
Yamashita, RA ;
Yin, JJ ;
Bryant, SH .
NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :383-387
[5]  
Matsuo Y, 1999, PROTEINS, V35, P70, DOI 10.1002/(SICI)1097-0134(19990401)35:1<70::AID-PROT7>3.3.CO
[6]  
2-0
[7]   Crystal structures of the SH2 domain of Grb2: Highlight on the binding of a new high-affinity inhibitor [J].
Nioche, P ;
Liu, WQ ;
Broutin, I ;
Charbonnier, F ;
Latreille, MT ;
Vidal, M ;
Roques, B ;
Garbay, C ;
Ducruix, A .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 315 (05) :1167-1177
[8]   Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor [J].
Schindler, T ;
Sicheri, F ;
Pico, A ;
Gazit, A ;
Levitzki, A ;
Kuriyan, J .
MOLECULAR CELL, 1999, 3 (05) :639-648
[9]   Cn3D: sequence and structure views for Entrez [J].
Wang, YL ;
Geer, LY ;
Chappey, C ;
Kans, JA ;
Bryant, SH .
TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (06) :300-302
[10]   MMDB: Entrez's 3D-structure database [J].
Wang, YL ;
Anderson, JB ;
Chen, J ;
Geer, LY ;
He, SQ ;
Hurwitz, DI ;
Liebert, CA ;
Madej, T ;
Marchler, GH ;
Marchler-Bauer, A ;
Panchenko, AR ;
Shoemaker, BA ;
Song, JS ;
Thiessen, PA ;
Yamashita, RA ;
Bryant, SH .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :249-252