BioMercator: integrating genetic maps and QTL towards discovery of candidate genes

被引：387

作者：

Arcade, A

Labourdette, A

Falque, M

Mangin, B

Chardon, F

Charcosset, A

Joets, J

机构：

[1] CNRS Genet Veg, UMR, INRA, UPS 11,INAPG, F-91190 Gif Sur Yvette, France

[2] INRA, F-31326 Castanet Tolosan, France

来源：

BIOINFORMATICS | 2004年 / 20卷 / 14期

关键词：

D O I：

10.1093/bioinformatics/bth230

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Breeding programs face the challenge of integrating information from genomics and from quantitative trait loci (QTL) analysis in order to identify genomic sequences controlling the variation of important traits. Despite the development of integrative databases, building a consensus map of genes, QTL and other loci gathered from multiple maps remains a manual and tedious task. Nevertheless, this is a critical step to reveal co-locations between genes and QTL. Another important matter is to determine whether QTL linked to same traits or related ones is detected in independent experiments and located in the same region, and represents a single locus or not. Statistical tools such as meta-analysis can be used to answer this question. BioMercator has been developed to automate map compilation and QTL meta-analysis, and to visualize co-locations between genes and QTL through a graphical interface.

引用

页码：2324 / 2326

页数：3

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