Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering

被引：33

作者：

Bretcanu, Oana ^{[1
]}

Misra, Superb K. ^{[1
]}

Yunos, D. Mohammad ^{[1
]}

Boccaccini, Aldo R. ^{[1
]}

Roy, Ipsita ^{[2
]}

Kowalczyk, Tomasz ^{[3
]}

Blonski, Slawomir ^{[3
]}

Kowalewski, Tomasz A. ^{[3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London, England

[2] Univ Westminster, Dept Mol & Appl Biosci, London W1R 8AL, England

[3] Polish Acad Sci IPPT PAN, Inst Fundamental Technol Res, Warsaw, Poland

来源：

MATERIALS CHEMISTRY AND PHYSICS | 2009年 / 118卷 / 2-3期

关键词：

Electrospinning; Nanofibers; Bioglass (R); Polyhydroxyalkanoates; Tissue engineering; BIOACTIVE GLASS; SCAFFOLDS; BONE; COMPOSITES; POLYMER; NANOTUBES; FOAMS;

D O I：

10.1016/j.matchemphys.2009.08.011

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Biodegradable polymeric nanofibrous coatings were obtained by electrospinning different polymer onto sintered 45S5 Bioglass (R)-based glass-ceramic pellets. The investigated polymers were (polyhydroxybutyrate) (P3HB), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) and a composite poly(caprolactone) (PCL) and poly(ethylene oxide) (PEO) (PCL-PEO). The fibrous coatings morphology was evaluated by optical microscopy and scanning electron microscopy. The electrospinning pro parameters were optimised to obtain reproducible coatings formed by a thin web of polymer nanofit In-vitro studies in simulated body fluid (SBF) were performed to investigate the bioactivity and minimisation of the substrates by inducing the formation of hydroxyapatite (HA) on the nano fiber-coated HA crystals were detected on all samples after 7 days of immersion in SBF, however the morphology the HA layer depended on the characteristic fibre diameter, which in turn was a function of the specific polymer-solvent system used. The bioactive and resorbable nanofibrous coatings can be used to the the surface topography of bioactive glass-ceramics for applications in tissue engineering scaffolds. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：420 / 426

页数：7

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