Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda

被引：50

作者：

Tumwebaze, Patrick ^{[1
]}

Tukwasibwe, Stephen ^{[1
]}

Taylor, Aimee ^{[4
,5
]}

Conrad, Melissa ^{[6
]}

Ruhamyankaka, Emmanuel ^{[1
]}

Asua, Victor ^{[1
]}

Walakira, Andrew ^{[1
]}

Nankabirwa, Joaniter ^{[1
]}

Yeka, Adoke ^{[2
]}

Staedke, Sarah G. ^{[7
]}

Greenhouse, Bryan ^{[6
]}

Nsobya, Samuel L. ^{[1
]}

Kamya, Moses R. ^{[1
,3
]}

Dorsey, Grant ^{[6
]}

Rosenthal, Philip J. ^{[6
]}

机构：

[1] Makerere Univ, Sch Publ Hlth, Infectious Dis Res Collaborat, Kampala, Uganda

[2] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda

[3] Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda

[4] Harvard T H Chan Sch Publ Hlth, Ctr Communicable Dis Dynam, Boston, MA USA

[5] Broad Inst MIT & Harvard, Cambridge, MA USA

[6] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[7] London Sch Hyg & Trop Med, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Malaria; Plasmodium falciparum; drug resistance; artemisinin; chloroquine; artemether; lumefantrine; artesunate; amodiaquine; dihydroartemisinin; piperaquine; pfcrt; pfmdr1; K13; PLASMODIUM-FALCIPARUM; MALARIA PARASITES; DIHYDROARTEMISININ-PIPERAQUINE; POLYMORPHISMS; SENSITIVITY; CHILDREN;

D O I：

10.1093/infdis/jiw614

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.

引用

页码：631 / 635

页数：5

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