MicroRNAs Modulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells

被引：52

作者：

Mazziotta, Chiara ^{[1
]}

Lanzillotti, Carmen ^{[1
]}

Iaquinta, Maria Rosa ^{[1
]}

Taraballi, Francesca ^{[2
,3
]}

Torreggiani, Elena ^{[1
]}

Rotondo, John Charles ^{[1
]}

Oton-Gonzalez, Lucia ^{[1
]}

Mazzoni, Elisa ^{[1
]}

Frontini, Francesca ^{[1
]}

Bononi, Ilaria ^{[1
]}

De Mattei, Monica ^{[1
]}

Tognon, Mauro ^{[1
]}

Martini, Fernanda ^{[1
,4
]}

机构：

[1] Univ Ferrara, Sch Med, Sect Expt Med, Dept Med Sci, 64b Fossato Mortara St, I-44121 Ferrara, Italy

[2] Houston Methodist Res Inst, Ctr Musculoskeletal Regenerat, 6670 Bertner Ave, Houston, TX 77030 USA

[3] Houston Methodist Hosp, Orthoped & Sports Med, 6565 Fannin St, Houston, TX 77030 USA

[4] Univ Ferrara, Lab Technol Adv Therapies LTTA, 70 Eliporto St, I-44121 Ferrara, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 05期

关键词：

mesenchymal stem cells; MSCs; microRNA; miRNA; bone; osteogenic differentiation; osteogenesis; cell differentiation; stem cells; miRNAome; bone regeneration;

D O I：

10.3390/ijms22052362

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have been closely studied in recent years, especially in view of their potential use for treating diseases and damaged tissues and organs. MSCs are capable of self-replication and differentiation into osteoblasts and are considered an important source of cells in tissue engineering for bone regeneration. Several epigenetic factors are believed to play a role in the osteogenic differentiation of MSCs, including microRNAs (miRNAs). MiRNAs are small, single-stranded, non-coding RNAs of approximately 22 nucleotides that are able to regulate cell proliferation, differentiation and apoptosis by binding the 3 ' untranslated region (3 '-UTR) of target mRNAs, which can be subsequently degraded or translationally silenced. MiRNAs control gene expression in osteogenic differentiation by regulating two crucial signaling cascades in osteogenesis: the transforming growth factor-beta (TGF-beta)/bone morphogenic protein (BMP) and the Wingless/Int-1(Wnt)/beta-catenin signaling pathways. This review provides an overview of the miRNAs involved in osteogenic differentiation and how these miRNAs could regulate the expression of target genes.

引用

页码：1 / 21

页数：21

共 190 条

[71] Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370 [J].