T-cell type lymphoproliferative disease of granular lymphocytes (LDGL) is equipped with a phenotypic pattern typical of effector cytotoxic cells

被引：9

作者：

Baesso, Ilenia ^{[1
]}

Pavan, Laura ^{[1
]}

Boscaro, Elisa ^{[1
]}

Miorin, Marta ^{[1
]}

Facco, Monica ^{[1
]}

Trentin, Livio ^{[1
]}

Agostini, Carlo ^{[1
]}

Zambello, Renato ^{[1
]}

Semenzato, Gianpietro ^{[1
]}

机构：

[1] Univ Padua, Sch Med, Dept Clin & Expt Med, Hematol & Clin Immunol Branch, Padua, Italy

来源：

LEUKEMIA RESEARCH | 2007年 / 31卷 / 03期

关键词：

T-cell lymphoproliferative disease of granular lymphocytes; GLs; CTLs; KIRs; NCRs; NK-CTLs;

D O I：

10.1016/j.leukres.2006.06.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

By analyzing the expression of several cytotoxic markers, killer-immunoglobulin-like receptors (KIRs), CD94/CD159, CD314 and natural cytotoxicity receptors (NCRs), in 22 CD3+ lymphoproliferative disease of granular lymphocyte (LDGL) patients we investigated whether granular lymphocytes (GLs) displayed the phenotype of fully differentiated cytotoxic cells. Our results demonstrate that GLs express a pattern consistent with fully differentiated CTLs. KIRs are expressed only in a fraction of patients (7/22), as is CD94/CD159 (5/22). In conclusion, GLs in CD3+ LDGL patients typically show the phenotype of fully differentiated CTL, whereas the expression of NK receptors does not represent a common feature of the proliferating clone. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：371 / 377

页数：7

共 32 条

[1] Human natural killer cell receptors and co-receptors [J].

Biassoni, R ;

Cantoni, C ;

Pende, D ;

Sivori, S ;

Parolini, S ;

Vitale, M ;

Bottino, C ;

Moretta, A .

IMMUNOLOGICAL REVIEWS, 2001, 181 :203-214

[2] Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors [J].

Bigouret, V ;

Hoffmann, T ;

Arlettaz, L ;

Villard, J ;

Colonna, M ;

Ticheli, A ;

Gratwohl, A ;

Samii, K ;

Chapuis, B ;

Rufer, N ;

Roosnek, E .

BLOOD, 2003, 101 (08) :3198-3204

[3] The natural killer-related receptor for HLA-C expressed on T cells from CD3(+) lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function [J].

Cambiaggi, A ;

Orengo, AM ;

Meazza, R ;

Sforzini, S ;

Tazzari, PL ;

Lauria, F ;

Raspadori, D ;

Zambello, R ;

Semenzato, G ;

Moretta, L ;

Ferrini, S .

BLOOD, 1996, 87 (06) :2369-2375

[4] Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes [J].

Epling-Burnette, PK ;

Painter, JS ;

Chaurasia, P ;

Bai, FQ ;

Wei, S ;

Djeu, JY ;

Loughran, TP .

BLOOD, 2004, 103 (09) :3431-3439

[5] Survival signals in leukemic large granular lymphocytes [J].

Epling-Burnette, PK ;

Loughran, TP .

SEMINARS IN HEMATOLOGY, 2003, 40 (03) :213-220

[6] Faces and phases of human CD8+ T-cell development [J].

Hamann, D ;

Roos, MTL ;

van Lier, RAW .

IMMUNOLOGY TODAY, 1999, 20 (04) :177-180

[7] Natural killer-type receptors for HLA class I antigens are clonally expressed in lymphoproliferative disorders of natural killer and T-cell type [J].

Hoffmann, T ;

de Libero, G ;

Colonna, M ;

Wodnar-Filipowicz, A ;

Passweg, J ;

Favre, G ;

Gratwohl, A ;

Tichelli, A .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 110 (03) :525-536

[8]

KASTENSPORTES C, 1994, BLOOD, V83, P767

[9]

Kothapalli R, 2003, INT J ONCOL, V22, P33

[10]

Lamy, 1998, Cancer Control, V5, P25

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