Transition-metal-free selective pyrimidines and pyridines formation from aromatic ketones, aldehydes and ammonium salts

被引：50

作者：

Chen, Jinjin ^{[1
]}

Meng, Huanxin ^{[1
]}

Zhang, Feng ^{[1
,2
]}

Xiao, Fuhong ^{[1
]}

Deng, Guo-Jun ^{[1
]}

机构：

[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environmentally Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China

[2] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China

来源：

GREEN CHEMISTRY | 2019年 / 21卷 / 19期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

DIELS-ALDER REACTIONS; MULTICOMPONENT REACTIONS; ALPHA; BETA-UNSATURATED KETONES; STEP SYNTHESIS; 3+3 ANNULATION; DERIVATIVES; CYCLOADDITIONS; NITRILES; HETEROCYCLES; DISCOVERY;

D O I：

10.1039/c9gc02077b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of pyrimidines and pyridines has been developed from readily available aromatic ketones, aldehydes and ammonium salts under transition-metal-free conditions. In this strategy, ammonium salts were used as nitrogen sources and only water was generated as a nontoxic byproduct. A catalytic amount of NaIO4 played an important role in the selectivity control, whereas substituted pyridines were dominantly formed in its absence.

引用

页码：5201 / 5206

页数：6

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