Association between gout and polymorphisms in SLC17A1 gene in male Han Chinese

被引:0
作者
Li, Ming [2 ]
Cheng, Zhifeng [2 ]
Li, Changgui [3 ]
Guo, Min [2 ]
Xu, Jinmei [2 ]
Tang, Yingying [2 ]
Zhao, Qingsong [2 ]
Kang, Yingying [2 ]
Du, Lili [2 ]
Hu, Yuhua [2 ]
Li, Qiang [1 ]
Zhang, Jinchao [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, 148 Baojian Rd, Harbin 150086, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 4, Dept Endocrinol & Metab, Harbin 150001, Heilongjiang, Peoples R China
[3] Qingdao Univ, Coll Med, Affiliated Hosp, Shandong Prov Key Lab Metab Dis, Qingdao 266071, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 02期
关键词
Single-nucleotide polymorphism; sodium-phosphate cotransporter proteins; gout; URIC-ACID; RENAL UNDEREXCRETION; RISK; LOCI;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localized to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular cells to urine. The SLC17A1 locus was also found to be associated with serum urate concentration. However, evidence for association with gout was equivocal. In current study, we investigated the association of the SLC17A1 locus with gout in male Han Chinese. This was a case-control study in a group of 400 male patients with gout and 424 gout-free male controls to genotype the single-nucleotide polymorphism rs1165196, rs1183201 and rs3799344 of SLC17A1 gene. There were significant differences between gout and control groups in the allele frequencies at rs1165196 (T806C; Ile269Thr, odds ratio (OR) 0.758, P=0.027) and rs1183201 (OR 0.745, P=0.018). The allele frequencies of rs3799344 were not significantly associated with the development of gout (OR 0.811, P=0.064). The association was found between genotypes at rs1165196 and rs1183201 (P=0.032 and P=0.029) and serum uric acid (sUA) levels. The genotype status of rs1183201 was significantly associated with sUA using Multivariate regression analysis. However, there were no differences in the distribution of genotypes at rs1165196 (OR 1.121, P>0.05) and rs1183201 (OR 0.887, P>0.05) in patients with gout with kidney stones and without kidney stones. Our data suggest that SLC17A1 polymorphisms were associated with the development of gout in male Han Chinese.
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页码:4913 / 4920
页数:8
相关论文
共 16 条
[1]   NPT1/SLC17A1 Is a Renal Urate Exporter in Humans and Its Common Gain-of-Function Variant Decreases the Risk of Renal Underexcretion Gout [J].
Chiba, Toshinori ;
Matsuo, Hirotaka ;
Kawamura, Yusuke ;
Nagamori, Shushi ;
Nishiyama, Takashi ;
Wei, Ling ;
Nakayama, Akiyoshi ;
Nakamura, Takahiro ;
Sakiyama, Masayuki ;
Takada, Tappei ;
Taketani, Yutaka ;
Suma, Shino ;
Naito, Mariko ;
Oda, Takashi ;
Kumagai, Hiroo ;
Moriyama, Yoshinori ;
Ichida, Kimiyoshi ;
Shimizu, Toru ;
Kanai, Yoshikatsu ;
Shinomiya, Nariyoshi .
ARTHRITIS & RHEUMATOLOGY, 2015, 67 (01) :281-287
[2]   Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study [J].
Dehghan, Abbas ;
Kottgen, Anna ;
Yang, Qiong ;
Hwang, Shih Jen ;
Kao, W. H. Linda ;
Rivadeneira, Fernando ;
Boerwinkle, Eric ;
Levy, Daniel ;
Hofman, Albert ;
Astor, Brad C. ;
Benjamin, Emelia J. ;
van Duijn, Cornelia M. ;
Witteman, Jacqueline C. ;
Coresh, Josef ;
Fox, Caroline S. .
LANCET, 2008, 372 (9654) :1953-1961
[3]   SLC2A9 influences uric acid concentrations with pronounced sex-specific effects [J].
Doering, Angela ;
Gieger, Christian ;
Mehta, Divya ;
Gohlke, Henning ;
Prokisch, Holger ;
Coassin, Stefan ;
Fischer, Guido ;
Henke, Kathleen ;
Klopp, Norman ;
Kronenberg, Florian ;
Paulweber, Bernhard ;
Pfeufer, Arne ;
Rosskopf, Dieter ;
Voelzke, Henry ;
Illig, Thomas ;
Meitinger, Thomas ;
Wichmann, H-Erich ;
Meisinger, Christa .
NATURE GENETICS, 2008, 40 (04) :430-436
[4]   The renal urate transporter SLC17A1 locus: confirmation of association with gout [J].
Hollis-Moffatt, Jade E. ;
Phipps-Green, Amanda J. ;
Chapman, Brett ;
Jones, Gregory T. ;
van Rij, Andre ;
Gow, Peter J. ;
Harrison, Andrew A. ;
Highton, John ;
Jones, Peter B. ;
Montgomery, Grant W. ;
Stamp, Lisa K. ;
Dalbeth, Nicola ;
Merriman, Tony R. .
ARTHRITIS RESEARCH & THERAPY, 2012, 14 (02)
[5]   Type 1 Sodium-dependent Phosphate Transporter (SLC17A1 Protein) Is a Cl--dependent Urate Exporter [J].
Iharada, Masafumi ;
Miyaji, Takaaki ;
Fujimoto, Takahiro ;
Hiasa, Miki ;
Anzai, Naohiko ;
Omote, Hiroshi ;
Moriyama, Yoshinori .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (34) :26107-26113
[6]   Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations [J].
Kolz, Melanie ;
Johnson, Toby ;
Sanna, Serena ;
Teumer, Alexander ;
Vitart, Veronique ;
Perola, Markus ;
Mangino, Massimo ;
Albrecht, Eva ;
Wallace, Chris ;
Farrall, Martin ;
Johansson, Asa ;
Nyholt, Dale R. ;
Aulchenko, Yurii ;
Beckmann, Jacques S. ;
Bergmann, Sven ;
Bochud, Murielle ;
Brown, Morris ;
Campbell, Harry ;
Connell, John ;
Dominiczak, Anna ;
Homuth, Georg ;
Lamina, Claudia ;
McCarthy, Mark I. ;
Meitinger, Thomas ;
Mooser, Vincent ;
Munroe, Patricia ;
Nauck, Matthias ;
Peden, John ;
Prokisch, Holger ;
Salo, Perttu ;
Salomaa, Veikko ;
Samani, Nilesh J. ;
Schlessinger, David ;
Uda, Manuela ;
Voelker, Uwe ;
Waeber, Gerard ;
Waterworth, Dawn ;
Wang-Sattler, Rui ;
Wright, Alan F. ;
Adamski, Jerzy ;
Whitfield, John B. ;
Gyllensten, Ulf ;
Wilson, James F. ;
Rudan, Igor ;
Pramstaller, Peter ;
Watkins, Hugh ;
Doering, Angela ;
Wichmann, H. -Erich ;
Spector, Tim D. ;
Peltonen, Leena .
PLOS GENETICS, 2009, 5 (06)
[7]   A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn) [J].
Li, Zhiqiang ;
Zhang, Zhao ;
He, Zangdong ;
Tang, Wei ;
Li, Tao ;
Zeng, Zhen ;
He, Lin ;
Shi, Yongyong .
CELL RESEARCH, 2009, 19 (04) :519-523
[8]  
Miyaji Takaaki, 2013, Curr Mol Pharmacol, V6, P88
[9]   Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output [J].
Perez-Ruiz, F ;
Calabozo, M ;
Erauskin, GG ;
Ruibal, A ;
Herrero-Beites, AM .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2002, 47 (06) :610-613
[10]   SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci [J].
Shi, YY ;
He, L .
CELL RESEARCH, 2005, 15 (02) :97-98