A comparative insight into the bioactivity of mono- and binuclear silver(I)-N-heterocyclic carbene complexes: synthesis, lipophilicity and substituent effect

被引：33

作者：

Asekunowo, Patrick O. ^{[1
]}

Haque, Rosenani A. ^{[1
]}

Razali, Mohd. R. ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Malaysia

来源：

REVIEWS IN INORGANIC CHEMISTRY | 2017年 / 37卷 / 01期

关键词：

Ag(I)-NHC complex; antibacterial activity; anticancer activity; lipophilicity; N-heterocyclic Carbene; N-HETEROCYCLIC CARBENE; BIS-BENZIMIDAZOLIUM SALTS; CARBENE-SILVER(I) ACETATE COMPLEXES; CRYSTAL-STRUCTURES; IN-VITRO; SILVER COMPLEXES; ANTIMICROBIAL ACTIVITY; ANTICANCER ACTIVITY; SILVER(I)-CARBENE COMPLEXES; NHC-SILVER(I) COMPLEXES;

D O I：

10.1515/revic-2016-0007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Silver(I)-N-heterocyclic carbene (Ag(I)-NHC) complexes of mononuclear and binuclear species, synthesised by our group and others in recent years, offer a fascinating outlook on their bioactivity. These complexes advance a range of adaptable structural patterns, leading to intra-specific variation in anticancer and antimicrobial activities. This study therefore reviews the synthesis, structural analysis and bioactivity of Ag complexes derived from mononuclear-NHC complexes either with coordinating or non-coordinating anions and binuclear NHC complexes. Specifically, the effect of stability, chain lengths and lipophilicity on the biological activity of recently reported Ag(I)-NHC complexes is reviewed. These complexes can be further explored as novel antibacterial and anticancer drugs in the nearest future.

引用

页码：29 / 50

页数：22

共 89 条

[1] Synthesis and structure of silver complexes with nicotinate-type ligands having antibacterial activities against clinically isolated antibiotic resistant pathogens [J].

Abu-Youssef, Morsy A. M. ;

Dey, Raja ;

Gohar, Yousry ;

Massoud, Alshima'a A. ;

Ohrstrom, Lars ;

Langer, Vratislav .

INORGANIC CHEMISTRY, 2007, 46 (15) :5893-5903

[2]

[Anonymous], INT J CHEM TECH RES

[3] Benzimidazole-based silver(I)-N-heterocyclic carbene complexes as anti-bacterials: synthesis, crystal structures and nucleic acids interaction studies [J].

Asekunowo, Patrick O. ;

Haque, Rosenani A. ;

Razali, Mohd. R. ;

Budagumpi, Srinivasa .

APPLIED ORGANOMETALLIC CHEMISTRY, 2015, 29 (03) :126-137

[4] Sterically modulated silver(I) complexes of N-benzyl-substituted N-heterocyclic carbenes: synthesis, crystal structures and bioactivity [J].

Asekunowo, Patrick O. ;

Haque, Rosenani A. ;

Razali, Mohd R. .

TRANSITION METAL CHEMISTRY, 2015, 40 (01) :79-88

[5] Counterion-induced modulation in biochemical properties of nitrile functionalized silver(I)-N-heterocyclic carbene complexes [J].

Asekunowo, Patrick O. ;

Haque, Rosenani A. .

JOURNAL OF COORDINATION CHEMISTRY, 2014, 67 (22) :3649-3663

[6] Dinuclear N-heterocyclic carbene complexes of silver(I), derived from imidazolium-linked cyclophanes [J].

Baker, MV ;

Brown, DH ;

Haque, RA ;

Skelton, BW ;

White, AH .

DALTON TRANSACTIONS, 2004, (21) :3756-3764

[7] Stable carbenes [J].

Bourissou, D ;

Guerret, O ;

Gabbaï, FP ;

Bertrand, G .

CHEMICAL REVIEWS, 2000, 100 (01) :39-91

[8] Stereochemical and structural characteristics of single- and double-site Pd(II)-N-heterocyclic carbene complexes: Promising catalysts in organic syntheses ranging from C-C coupling to olefin polymerizations [J].

Budagumpi, Srinivasa ;

Haque, Rosenani A. ;

Salman, Abbas Washeel .

COORDINATION CHEMISTRY REVIEWS, 2012, 256 (17-18) :1787-1830

[9] Antimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids [J].

Busetti, Alessandro ;

Crawford, Deborah E. ;

Earle, Martyn J. ;

Gilea, Manuela A. ;

Gilmore, Brendan F. ;

Gorman, Sean P. ;

Laverty, Garry ;

Lowry, Andrew F. ;

McLaughlin, Martin ;

Seddon, Kenneth R. .

GREEN CHEMISTRY, 2010, 12 (03) :420-425

[10] In Vitro and Murine Efficacy and Toxicity Studies of Nebulized SCC1, a Methylated Caffeine-Silver(I) Complex, for Treatment of Pulmonary Infections [J].

Cannon, Carolyn L. ;

Hogue, Lisa A. ;

Vajravelu, Ravy K. ;

Capps, George H. ;

Ibricevic, Aida ;

Hindi, Khadijah M. ;

Kascatan-Nebioglu, Aysegul ;

Walter, Michael J. ;

Brody, Steven L. ;

Youngs, Wiley J. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (08) :3285-3293

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