Mechanism and applications of Rieske non-heme iron dioxygenases

被引:86
作者
Wackett, LP [1 ]
机构
[1] Univ Minnesota, Dept Biochem, Mol Biol & Biophys & Biotechnol Inst, St Paul, MN 55108 USA
关键词
dioxygenase; Rieske; bacteria; mechanism; Cis-diol; chiral synthon;
D O I
10.1016/S0141-0229(02)00129-1
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Oxygenases are a broad class of enzymes which are important for the catabolism or recycling of organic matter in the environment., Bacterial catabolism of hydrocarbons and substituted aromatic compounds often uses dioxygenases containing a Rieske iron-sulfur cluster and a non-heme iron center. The dioxygenases have been useful in producing oxygenated materials directly, or indirectly by generating chiral synthetic intermediates. The recent availability of protein structures and gene sequences provides new opportunities for expanding the usefulness of this enzyme class. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:577 / 587
页数:11
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