Digital micromirror device based ophthalmoscope with concentric circle scanning

被引:13
作者
Damodaran, Mathi [1 ]
Vienola, Kari V. [1 ]
Braaf, Boy [1 ]
Vermeer, Koenraad A. [2 ]
de Boer, Johannes F. [1 ]
机构
[1] Vrije Univ Amsterdam, Dept Phys & Astron, LaserLaB, De Boelelaan 1081, NL-1081 HV Amsterdam, Netherlands
[2] Rotterdam Ophthalm Inst, Schiedamse Vest 160D, NL-3011 BH Rotterdam, Netherlands
关键词
HUMAN OCULAR FUNDUS; LASER OPHTHALMOSCOPE; FLUORESCENCE MICROSCOPY; HIGH-SPEED; CAMERA; ILLUMINATION; TRACKING;
D O I
10.1364/BOE.8.002766
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Retinal imaging is demonstrated using a novel scanning light ophthalmoscope based on a digital micromirror device with 810 nm illumination. Concentric circles were used as scan patterns, which facilitated fixation by a human subject for imaging. An annular illumination was implemented in the system to reduce the background caused by corneal reflections and thereby to enhance the signal-to-noise ratio. A 1.9-fold increase in the signal-to-noise ratio was found by using an annular illumination aperture compared to a circular illumination aperture, resulting in a 5-fold increase in imaging speed and a better signal-to-noise ratio compared to our previous system. We tested the imaging performance of our system by performing non-mydriatic imaging on two subjects at a speed of 7 Hz with a maximum 20 degrees (diameter) field of view. The images were shot noise limited and clearly show various anatomical features of the retina with high contrast. (C) 2017 Optical Society of America.
引用
收藏
页码:2766 / 2780
页数:15
相关论文
共 35 条
[1]  
Atchison DA, 2000, OPTICS HUMAN EYE, p[34, 166, 251]
[2]   Studying different illumination patterns for resolution improvement in fluorescence microscopy [J].
Chakrova, Nadya ;
Heintzmann, Rainer ;
Rieger, Bernd ;
Stallinga, Sjoerd .
OPTICS EXPRESS, 2015, 23 (24) :31367-31383
[3]  
Charman W.N., 1991, VISUAL OPTICS INSTRU, P1
[4]   Optimal parameters for retinal illumination and imaging in fundus cameras [J].
DeHoog, E. ;
Schwiegerling, J. .
APPLIED OPTICS, 2008, 47 (36) :6769-6777
[5]   SPECTRAL REFLECTANCE OF THE HUMAN OCULAR FUNDUS [J].
DELORI, FC ;
PFLIBSEN, KP .
APPLIED OPTICS, 1989, 28 (06) :1061-1077
[6]   REFLECTOMETRY WITH A SCANNING LASER OPHTHALMOSCOPE [J].
ELSNER, AE ;
BURNS, SA ;
HUGHES, GW ;
WEBB, RH .
APPLIED OPTICS, 1992, 31 (19) :3697-3710
[7]  
Elsner Ann E., 1993, P19
[8]  
European Machine Vision Association, 2016, Report
[9]   Line-scanning laser ophthalmoscope [J].
Hammer, Daniel X. ;
Ferguson, R. Daniel ;
Ustun, Teoman E. ;
Bigelow, Chad E. ;
Iftimia, Nicusor V. ;
Webb, Robert H. .
JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (04)
[10]   Quantitative reflection spectroscopy at the human ocular fundus [J].
Hammer, M ;
Schweitzer, D .
PHYSICS IN MEDICINE AND BIOLOGY, 2002, 47 (02) :179-191