共 54 条
Benchmarking to the Gold Standard: Hyaluronan-Oxime Hydrogels Recapitulate Xenograft Models with In Vitro Breast Cancer Spheroid Culture
被引:61
作者:

Baker, Alexander E. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada
Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Bahlmann, Laura C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Tam, Roger Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada
Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Liu, Jeffrey C.
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h-index: 0
机构:
Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Ganesh, Ahil N.
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h-index: 0
机构:
Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada
Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Mitrousis, Nikolaos
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h-index: 0
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Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Marcellus, Richard
论文数: 0 引用数: 0
h-index: 0
机构:
MaRS Ctr, Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Spears, Melanie
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h-index: 0
机构:
MaRS Ctr, Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada
Univ Toronto, Dept Lab Med & Pathol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Bartlett, John M. S.
论文数: 0 引用数: 0
h-index: 0
机构:
MaRS Ctr, Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Cescon, David W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hlth Network, Princess Margaret Canc Ctr, 610 Univ Ave, Toronto, ON M5G 2C1, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Bader, Gary D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

Shoichet, Molly S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada
Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada
Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
机构:
[1] Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
[2] Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada
[3] Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada
[4] MaRS Ctr, Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada
[5] Univ Toronto, Dept Lab Med & Pathol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
[6] Univ Hlth Network, Princess Margaret Canc Ctr, 610 Univ Ave, Toronto, ON M5G 2C1, Canada
[7] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada
基金:
加拿大自然科学与工程研究理事会;
关键词:
3D cell culture;
breast cancer;
drug screening;
hyaluronic acid;
hydrogels;
CELLS;
ACID;
GROWTH;
TISSUE;
CD44;
DEGRADATION;
EXPRESSION;
VIABILITY;
RESPONSES;
LAMININ;
D O I:
10.1002/adma.201901166
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Many 3D in vitro models induce breast cancer spheroid formation; however, this alone does not recapitulate the complex in vivo phenotype. To effectively screen therapeutics, it is urgently needed to validate in vitro cancer spheroid models against the gold standard of xenografts. A new oxime-crosslinked hyaluronan (HA) hydrogel is designed, manipulating gelation rate and mechanical properties to grow breast cancer spheroids in 3D. This HA-oxime breast cancer model maintains the gene expression profile most similar to that of tumor xenografts based on a pan-cancer gene expression profile (comprising 730 genes) of three different human breast cancer subtypes compared to Matrigel or conventional 2D culture. Differences in gene expression between breast cancer cultures in HA-oxime versus Matrigel or 2D are confirmed for 12 canonical pathways by gene set variation analysis. Importantly, drug response is dependent on the culture method. Breast cancer cells respond better to the Rac inhibitor (EHT-1864) and the PI3K inhibitor (AZD6482) when cultured in HA-oxime versus Matrigel. This study demonstrates the superiority of an HA-based hydrogel as a platform for in vitro breast cancer culture of both primary, patient-derived cells and cell lines, and provides a hydrogel culture model that closely matches that in vivo.
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页数:11
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Van Dyke, Terry
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Ctr Adv Preclin Res, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[10]
Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor a in breast cancer cells
[J].
Edjekouane, Lydia
;
Benhadjeba, Samira
;
Jangal, Maika
;
Fleury, Hubert
;
Gevry, Nicolas
;
Carmona, Euridice
;
Tremblay, Andre
.
ONCOTARGET,
2016, 7 (47)
:77276-77290

Edjekouane, Lydia
论文数: 0 引用数: 0
h-index: 0
机构:
CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada
Univ Montreal, Fac Med, Dept Biochem & Mol Med, Montreal, PQ H3T 1J4, Canada CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

Benhadjeba, Samira
论文数: 0 引用数: 0
h-index: 0
机构:
CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada
Univ Montreal, Fac Med, Dept Biochem & Mol Med, Montreal, PQ H3T 1J4, Canada CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

Jangal, Maika
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

Fleury, Hubert
论文数: 0 引用数: 0
h-index: 0
机构:
CHUM Res Ctr, Inst Canc Montreal, Montreal, PQ H2X 0A9, Canada CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

Gevry, Nicolas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

Carmona, Euridice
论文数: 0 引用数: 0
h-index: 0
机构:
CHUM Res Ctr, Inst Canc Montreal, Montreal, PQ H2X 0A9, Canada CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

Tremblay, Andre
论文数: 0 引用数: 0
h-index: 0
机构:
CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada
Univ Montreal, Fac Med, Dept Biochem & Mol Med, Montreal, PQ H3T 1J4, Canada
Univ Montreal, Fac Med, Dept Obstet & Gynecol, Montreal, PQ H3T 1J4, Canada CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada