Crystal structure, cytotoxicity and action mechanism of Zn(II)/Mn(II) complexes with isoquinoline ligands

被引：23

作者：

Wang, Feng-Yang ^{[1
]}

Xi, Qian-Yu ^{[1
]}

Huang, Ke-Bin ^{[1
]}

Tang, Xiao-Ming ^{[1
]}

Chen, Zhen-Feng ^{[1
]}

Liu, Yan-Cheng ^{[1
]}

Liang, Hong ^{[1
]}

机构：

[1] Guangxi Normal Univ, Sch Chem & Chem Engn, Guangxi Key Lab Chem & Molecular Engn Med Resourc, Guilin 541004, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2017年 / 169卷

基金：

中国国家自然科学基金;

关键词：

Isoquinoline derivatives; Zn(II)/Mn(II) complexes; Crystal structure; Antitumor activity; Action mechanism; DINUCLEAR ZINC(II) COMPLEXES; METAL-COMPLEXES; DNA-BINDING; IN-VITRO; PLATINUM(II) COMPLEXES; OXIDATIVE STRESS; CARCINOMA-CELLS; MITOCHONDRIA; COPPER(II); APOPTOSIS;

D O I：

10.1016/j.jinorgbio.2017.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four 112-CI bridged dinuclear metal complexes with isoquinoline ligands, (MPDQ)(2)Zn2CI4 (1) (MPDQ = 4.5methylenedioxy-1-pyridinedihydroisoquinoline), (PYP)(2)Zn2CI4 (2) (PYP = 5-pyridin-2-y1-11,31dioxolo[4,5asoquinoline), (MPDQ)(2)Mn2CI4 (3),and (PYP)(2)Mn2CI4 (4) were synthesized and characterized. All complexes exhibited strong proliferation inhibition activity against various cancer cells. The underlying molecular mechanisms through which they caused the cancer cell death were also elucidated. Induction of apoptosis in MGC803 cells by complex 2 was evidenced by annexin V/PI detection and DiD/DAPI staining assay. Further investigation revealed that complex 2 was able to induce intrinsic pathway-dependent apoptosis in cancer cells by triggering DNA damage which was caused by the overproduction of reactive oxygen species. Based on these studies, we suggest that Zn(II) complexes containing isoquinoline ligands can be developed as candidates for anti-cancer chemotherapeutics. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：23 / 31

页数：9

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