Neuro-Immune Cell Units: A New Paradigm in Physiology

被引：168
作者：
Godinho-Silva, Cristina [1 ]
Cardoso, Filipa [1 ]
Veiga-Fernandes, Henrique [1 ]
机构：
[1] Champalimaud Ctr Unknown, Champalimaud Res, P-1400038 Lisbon, Portugal
来源：
ANNUAL REVIEW OF IMMUNOLOGY, VOL 37, 2019 | 2019年 / 37卷
基金：
欧盟地平线“2020”; 欧洲研究理事会;
关键词：
neuroimmunology; neuro-immune cell units; neuroimmune interactions; mucosal immunology; immunophysiology; INNATE LYMPHOID-CELLS; SYMPATHETIC-NERVOUS-SYSTEM; VASOACTIVE-INTESTINAL-PEPTIDE; ENTERIC GLIAL-CELLS; BONE-MARROW; VAGUS NERVE; DENDRITIC CELLS; SUBSTANCE-P; NEUROPEPTIDE-Y; ANTIINFLAMMATORY PATHWAY;
D O I：
10.1146/annurev-immunol-042718-041812
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interplay between the immune and nervous systems has been acknowledged in the past, but only more recent studies have started to unravel the cellular and molecular players of such interactions. Mounting evidence indicates that environmental signals are sensed by discrete neuro-immune cell units (NICUs), which represent defined anatomical locations in which immune and neuronal cells colocalize and functionally interact to steer tissue physiology and protection. These units have now been described in multiple tissues throughout the body, including lymphoid organs, adipose tissue, and mucosal barriers. As such, NICUs are emerging as important orchestrators of multiple physiological processes, including hematopoiesis, organogenesis, inflammation, tissue repair, and thermogenesis. In this review we focus on the impact of NICUs in tissue physiology and how this fast-evolving field is driving a paradigm shift in our understanding of immunoregulation and organismal physiology.
引用
收藏
页码：19 / 46
页数：28
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