Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs - biological activities and SAR studies

被引：55

作者：

Faheem ^{[1
]}

Karan Kumar, Banoth ^{[1
]}

Chandra Sekhar, Kondapalli Venkata Gowri ^{[2
]}

Chander, Subhash ^{[3
]}

Kunjiappan, Selvaraj ^{[4
]}

Murugesan, Sankaranarayanan ^{[1
]}

机构：

[1] Birla Inst Technol & Sci Pilani, Dept Pharm, Med Chem Res Lab, Pilani Campus, Pilani 333031, Rajasthan, India

[2] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus, Hyderabad 500078, Telangana, India

[3] Amity Univ Uttar Pradesh, Amity Inst Phytomed & Phytochem, Noida 201313, India

[4] Kalasalingam Acad Res & Educ, Dept Biotechnol, Krishnankoil 626126, Tamil Nadu, India

来源：

RSC ADVANCES | 2021年 / 11卷 / 20期

关键词：

ANTIDEPRESSANT-LIKE ACTIVITY; IN-VITRO; PRAZIQUANTEL DERIVATIVES; ANTIBACTERIAL ACTIVITY; DOPAMINE RELEASE; ENDOGENOUS AMINE; MULTICOMPONENT REACTIONS; ANIMAL-MODEL; TETRAHYDROISOQUINOLINES; INHIBITORS;

D O I：

10.1039/d1ra01480c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Isoquinoline alkaloids are a large group of natural products in which 1,2,3,4-tetrahydroisoquinolines (THIQ) form an important class. THIQ based natural and synthetic compounds exert diverse biological activities against various infective pathogens and neurodegenerative disorders. Due to these reasons, the THIQ heterocyclic scaffold has garnered a lot of attention in the scientific community which has resulted in the development of novel THIQ analogs with potent biological activity. The present review provides a much-needed update on the biological potential of THIQ analogs, their structural-activity relationship (SAR), and their mechanism of action. In addition, a note on commonly used synthetic strategies for constructing the core scaffold has also been discussed.

引用

收藏

页码：12254 / 12287

页数：34

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