Signaling Cascades Governing Entry into and Exit from Host Cells by Toxoplasma gondii

被引:46
作者
Bisio, Hugo [1 ]
Soldati-Favre, Dominique [1 ]
机构
[1] Univ Geneva, Dept Microbiol & Med Mol, Ctr Med Univ, CH-1211 Geneva 4, Switzerland
来源
ANNUAL REVIEW OF MICROBIOLOGY, VOL 73 | 2019年 / 73卷
基金
欧盟地平线“2020”; 欧洲研究理事会;
关键词
Apicomplexa; Toxoplasma gondii; motility; egress; microneme; signaling; calcium; cyclic nucleotides; phosphatidic acid; kinase; diacylglycerol kinase; guanylate cyclase; DEPENDENT PROTEIN-KINASE; GUANYLYL CYCLASE ACTIVITY; MICRONEME SECRETION; INTRACELLULAR CALCIUM; PHOSPHATIDIC-ACID; LYTIC CYCLE; XANTHURENIC ACID; PLASMA-MEMBRANE; EGRESS; INVASION;
D O I
10.1146/annurev-micro-020518-120235
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The Apicomplexa phylum includes a large group of obligate intracellular protozoan parasites responsible for important diseases in humans and animals. Toxoplasma gondii is a widespread parasite with considerable versatility, and it is capable of infecting virtually any warm-blooded animal, including humans. This outstanding success can be attributed at least in part to an efficient and continuous sensing of the environment, with a ready-to-adapt strategy. This review updates the current understanding of the signals governing the lytic cycle of T. gondii, with particular focus on egress from infected cells, a key step for balancing survival, multiplication, and spreading in the host. We cover the recent advances in the conceptual framework of regulation of microneme exocytosis that ensures egress, motility, and invasion. Particular emphasis is given to the trigger molecules and signaling cascades regulating exit from host cells.
引用
收藏
页码:579 / 599
页数:21
相关论文
共 142 条
[1]   Melatonin and IP3-induced Ca2+ Release from Intracellular Stores in the Malaria Parasite Plasmodium falciparum within Infected Red Blood Cells [J].
Alves, Eduardo ;
Bartlett, Paula J. ;
Garcia, Celia R. S. ;
Thomas, Andrew P. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (07) :5905-5912
[2]  
[Anonymous], 2011, TOXINS
[3]   Adhesion of Toxoplasma gondii tachyzoite-infected vehicle leukocytes to capillary endothelial cells triggers timely parasite egression [J].
Baba, Minami ;
Batanova, Tatiana ;
Kitoh, Katsuya ;
Takashima, Yasuhiro .
SCIENTIFIC REPORTS, 2017, 7
[4]   Cyclic nucleotide signalling in malaria parasites [J].
Baker, David A. ;
Drought, Laura G. ;
Flueck, Christian ;
Nofal, Stephanie D. ;
Patel, Avnish ;
Penzo, Maria ;
Walker, Eloise M. .
OPEN BIOLOGY, 2017, 7 (12)
[5]   A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission [J].
Baker, David A. ;
Stewart, Lindsay B. ;
Large, Jonathan M. ;
Bowyer, Paul W. ;
Ansell, Keith H. ;
Jimenez-Diaz, Mar-A B. ;
El Bakkouri, Majida ;
Birchall, Kristian ;
Dechering, Koen J. ;
Bouloc, Nathalie S. ;
Coombs, Peter J. ;
Whalley, David ;
Harding, Denise J. ;
Smiljanic-Hurley, Ela ;
Wheldon, Mary C. ;
Walker, Eloise M. ;
Dessens, Johannes T. ;
Lafuente, Maria Jose ;
Sanz, Laura M. ;
Gamo, Francisco-Javier ;
Ferrer, Santiago B. ;
Hui, Raymond ;
Bousema, Teun ;
Angulo-Barturen, I. Igo ;
Merritt, Andy T. ;
Croft, Simon L. ;
Gutteridge, Winston E. ;
Kettleborough, Catherine A. ;
Osborne, Simon A. .
NATURE COMMUNICATIONS, 2017, 8
[6]   Inositol trisphosphate and calcium signalling mechanisms [J].
Berridge, Michael J. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2009, 1793 (06) :933-940
[7]   Lipidomic analysis of Toxoplasma gondii tachyzoites rhoptries:: further insights into the role of cholesterol [J].
Besteiro, Sebastien ;
Bertrand-Michel, Justine ;
Lebrun, Maryse ;
Vial, Henri ;
Dubremetz, Jean-Francois .
BIOCHEMICAL JOURNAL, 2008, 415 (01) :87-96
[8]   The moving junction of apicomplexan parasites: a key structure for invasion [J].
Besteiro, Sebastien ;
Dubremetz, Jean-Francois ;
Lebrun, Maryse .
CELLULAR MICROBIOLOGY, 2011, 13 (06) :797-805
[9]   Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito [J].
Billker, O ;
Lindo, V ;
Panico, M ;
Etienne, AE ;
Paxton, T ;
Dell, A ;
Rogers, M ;
Sinden, RE ;
Morris, HR .
NATURE, 1998, 392 (6673) :289-292
[10]   Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites [J].
Billker, Oliver ;
Lourido, Sebastian ;
Sibley, L. David .
CELL HOST & MICROBE, 2009, 5 (06) :612-622