Studies on microbial transformation of albendazole by soil fungi

被引：0
作者：
Prasad, G. Shyam
Girisham, S. [1 ]
Reddy, S. M.
机构：
[1] Kakatiya Univ, Dept Microbiol, Warangal 506009, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF BIOTECHNOLOGY | 2009年 / 8卷 / 04期
关键词：
Albendazole sulfoxide; albendazole sulfone; biotransformation; fungi; BIOTRANSFORMATION; MONOOXYGENASES; METABOLITES; OXIDATION; CATTLE;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Soil enrichment technique was followed to isolate the fungi capable of performing biotransformation of albendazole. Among the 5 fungi isolated, Aspergillus fumigatus, A. niger and Penicillium chrysogenum could transform albendazole to one metabolite and Fusarium moniliforme could transform albendazole to two metabolites. The transformation was confirmed by HPLC. Based on LC-MS-MS analysis, the metabolites formed were predicted to be albendazole sulfoxide and albendazole sulfone. The results support that the soil enrichment is. a promising technique for isolation of fungi with industrial applicability, viz. production of active metabolites from drugs.
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页码：425 / 429
页数：5
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