Bacterial infection microenvironment sensitive prodrug micelles with enhanced photodynamic activities for infection control

被引：45

作者：

Wang, Shuting ^{[1
]}

Fang, Yu ^{[1
]}

Zhang, Zequn ^{[1
]}

Jin, Qiao ^{[1
]}

Ji, Jian ^{[1
]}

机构：

[1] Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Minist Educ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

来源：

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS | 2021年 / 40卷

关键词：

Photodynamic therapy; pH-sensitive; Antibacterial; Prodrug micelles;

D O I：

10.1016/j.colcom.2020.100354

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Because of the severe antibiotic resistance, photodynamic therapy is considered as a potent method for the treatment of bacterial infection with bare drug resistance. However, its therapeutic efficacy is not always satisfactory in practical treatment. In this study, pH-responsive prodrug micelles were prepared by conjugation of chlorin e6 to polyethylene glycol-b-poly(2-(hexamethyleneimino) ethyl methacrylate-co-aminoethyl methacrylate) for improving the antimicrobial activity of photodynamic therapy. The micelles were negatively charged in normal physiological environment, which was very important for long blood circulation. However, the micelles could turn to be positively charged in bacterial infection microenvironment and then adhere to negatively charged bacterial membranes, which could significantly improve their antibacterial activity against both methicillin-resistant Staphylococcus aureus and Escherichia coli after laser irradiation. The in vivo experiment showed excellent antibacterial effect of pH-sensitive micelles in a subcutaneous infection model. The micelles showed great potential in the photodynamic therapy of stubborn bacterial infections.

引用

页数：12

共 34 条

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