Adenosine in sperm physiology

被引：24

作者：

Bellezza, Ilaria ^{[1
]}

Minelli, Alba ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Med Sperimentale, Polo Unico St Andrea Fratte, Piazzale Gambuli, I-06132 Perugia, Italy

来源：

MOLECULAR ASPECTS OF MEDICINE | 2017年 / 55卷

关键词：

Spermatogenesis; Epididymal maturation; Capacitation; Acrosome reaction; Adenosine receptors; PROTEIN-TYROSINE PHOSPHORYLATION; SOLUBLE ADENYLYL-CYCLASE; FERTILIZATION PROMOTING PEPTIDE; ENDOTHELIAL GROWTH-FACTOR; BETA-GAMMA-SUBUNITS; ACROSOME REACTION; MOUSE SPERM; HUMAN-SPERMATOZOA; MAMMALIAN SPERM; ZONA-PELLUCIDA;

D O I：

10.1016/j.mam.2016.11.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has long been known that ATP and cAMP are deeply involved in sperm function whereas the role of adenosine and adenosine receptors is still far from being totally construed. The presence of adenosine in male reproductive tract and adenosine receptors on spermatozoa is strongly suggestive of a functional role of these receptors in sperm physiology and function. Spermatozoa are highly differentiated cells with fertility as the only goal. This paper, by an extensive review of the literature, outlines our current understanding of the role and effects of adenosine and adenosine receptors in spermatogenesis and in the acquisition of sperm fertilizing capacity which occurs in the femal genital tract, where the motile sperm fertilize an egg to form a zygote. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：102 / 109

页数：8

共 174 条

[1]

Adler Kenneth B, 2013, Front Endocrinol (Lausanne), V4, P129, DOI 10.3389/fendo.2013.00129

[2] Sperm capacitation: a distant landscape glimpsed but unexplored [J].